Veterinary Toxicology Basic and Clinical Principles - Tabla de Contenido | Page 3

Contents ix

7.

Acute toxicity effects 101 Physiologically based toxicokinetics 135

Teratogenic effects 103 Parameter estimation and Long-term chronic effects identifiability 138

Minimum required performance limits and

Pesticide substances / residues from consumption of stockfeed treated with agricultural Chemicals

Biocidal substances used in animal

110 Magdalini Sachana and Alan Jeffrey Hargreaves

husbandry 111 Introduction 143

Feed additives legislation 112 In vivo models in toxicity testing 144 Technological additives 114 Introduction 144

for food safety 115 Cutaneous toxicity testing 147 Establishment of European Community Genotoxicity testing 147

Maximum residue level 120 Immunotoxicity 148 Establishment of codex maximum residue Transgenic animals in toxicity testing 149 limits for drugs and feed additives 122 In vitro models of toxicity testing 149

Drug withdrawal / withholding periods 123 Introduction 149 Industrial Chemicals 124 Types of cell culture system used in toxicity Concluding remarks and future directions 127 testing 150 References 127 Endpoint determination for in vitro testing

Toxicokinetics in veterinary

Systems 152

Excretion 133 Analytical tools for proteomic analyses 161

Empirical( compartmental) toxicokinetic The proteome and sample complexity 161 models 133 Two-dimensional gel electrophoresis 162 Introduction 133 High performance liquid Measures of absorption 134 chromatography 162 Volume of distribution 134 Protein and peptide microarrays 163 Clearance 135 Mass spectrometry 163 Half-life 135 Bioinformatics tools 164