viii Contents
Pesticides Insecticides Rodenticides Other pesticides Oil Feed associated toxicants Drugs and related compounds Household products Toxins Plants Other toxins
Concluding remarks and future directions
References
4. Chemicals of terrorism
Tina Wismer
Introduction
Chlorine gas Background Pharmacokinetics / toxicokinetics Mechanism of action Toxicity Treatment Concluding remarks Phosgene Background Pharmacokinetics / toxicokinetics
Mechanism of action Toxicity Treatment Concluding remarks
Mustard gas Background Pharmacokinetics / toxicokinetics Mechanism of action Toxicity Treatment Concluding remarks
Lewisite Background Pharmacokinetics / toxicokinetics Mechanism of action Toxicity Treatment Concluding remarks
Phosgene oxime Background Pharmacokinetics / toxicokinetics Mechanism of action Toxicity Treatment Concluding remarks
51 52 52 53 53 53 54 54 54 55 55
55 56
61 62 62 62 62 62 63 63 63 63 63 63 64 64 64 65 65 65 65 65 66 67 67 67 67 67 68 68 69 69 69 69 69 69 70 70
Cyanide and hydrogen cyanide |
70 |
Background |
70 |
Pharmacokinetics / toxicokinetics |
70 |
Mechanism of action |
71 |
Toxicity |
71 |
Treatment |
71 |
Concluding remarks |
72 |
Military nerve agents |
72 |
Background |
72 |
Pharmacokinetics / toxicokinetics |
73 |
Mechanism of action |
73 |
Toxicity |
73 |
Treatment |
74 |
Concluding remarks |
75 |
References |
75 |
5. Regulatory considerations in veterinary toxicology
Susan J. Bright-Ponte and Tong Zhou
Introduction Brief history of the Food and Drug
Administration FDA organization
FDA Center for Veterinary Medicine Overview Regulation of animal health products— Jurisdiction considerations and regulatory definitions New animal drug approval Target animal safety evaluation Human food safety assessment Approval
Post-approval surveillance activities
Overview of CVM ' s pharmacovigilance program Communication of safety Information Animal food Concluding remarks and future directions
References
6. Regulatory aspects for the drugs and Chemicals used in food-producing animals in the European Union
Arturo Anadón, María-Rosa Martínez- Larrañaga, Irma Ares, and María- Aránzazu Martínez
Introduction Veterinary medicinal product legislation
Marketing authorization procedures
Human health risks from drug residues in foods
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