Veterinary Toxicology Basic and Clinical Principles - Tabla de Contenido

Contents

Contributors Preface
Section A General
1. Concepts in veterinary toxicology
Roger O. McCIellan xxix xxxiii
Toxicant-induced responses
26
Describing exposure-dose-response
relationships for noncancer endpoints
27
Cancer as an endpoint
29
New potential endpoints
29
Concluding remarks and future
directions
30
Dedication
3I
Acknowledgments
31
PostScript
32
References
32
Introduction
3
Historical perspective
4
Historical events
4
Textbooks
5
Organizations
6
Evolution of veterinary toxicology
7
Roots in veterinary medicine and toxicology
7
Emergence of science-based
toxicology
7
Toxicology joined to the risk paradigm
9
A framework for acquiring information
15
Linkages from sources to health
impacts
15
Toxicokinetics
17
Toxicodynamics
17
Veterinary toxicology is multifaceted
18
Sources of information
| 9
Case observations in the species of
interest
19
Epidemiological / epizootiological
studies
19
Experimentation
20
Schematic experimental
designs
21
Acquiring toxicokinetic
data
21
Acquiring exposure-dose-response
data
22
Toxicologic descriptors
24
Toxicology rooted in observations
24
Quantifying exposure
24
Describing absorption, distribution, metabolism, and
excretion
25
2. Epidemiology of animal poisonings in the United States
Tina Wismer
Introduction
37
Background
37
Demographics
38
Dogs
38
Cats
39
Other species
39
Toxic agents
39
Seasonality
41
Signs and outcome
42
References
42
3. Epidemiology of animal poisonings in Europe
Francesca Caloni, Philippe Berny, Siska Croubels, and Magdalini Sachana
Introduction 45
Species involved
46
Toxic classes
47
Non-metals and metalloids 48 Metals 48
Copper
48
Lead
48
Other metals and inorganic compounds 49
vii