Veterinary Toxicology Basic and Clinical Principles - Tabla de Contenido | Page 11

Contents xvii

Morpholines 589 Amides 590 Others 590 Endocrine disruption 590 Treatment 591 Concluding remarks and future directions 591 References 591

Section H Rodenticides

45. Anticoagulant rodenticides

John P. Buchweitz

Introduction 597 Oral anticoagulants 597 Synthetic rodenticides 598 Primary mechanism of action and metabolism 599 Primary mechanism of action 599 Metabolism 600

Toxicity 600 Clinical diagnosis 600 Necropsy / autopsy 602

Toxicokinetics 602 Bioavailability 602 Distribution 603 Elimination 603 Duration 603

Treatment 603 General 603 Supportive 603 Specific 603 Resistance 604 Pest management 604 Regulations 604

Food safety 604 Concluding remarks and future directions 604 References 605

46. Non-anticoagulant rodenticides

Ramesh C. Gupta, HuiChang Chae, and Kirsten B. Ezell

Strychnine 611 Introduction 611 Background 612 Toxicokinetics 612 Mechanism of action 612 Toxicity 612

Diagnosis 613 Treatment 613 Conclusion 613

Bromethalin 613 Introduction 613

Treatment 615 Conclusion 615

Cholecalciferol 615 Introduction 615

Mechanism of action 616

Conclusion 616

Toxicity 617

Fluoroacetate 618 Introduction 618

Alpha-naphthyl thiourea 620 Introduction Toxicokinetics and mechanism of

620

action 620 Toxicity 620 Diagnosis 621

Treatment 622 Conclusion 622