Over the summer, Allie Loeffler, COM '24 had the opportunity to work with Dr. Jason Wilson, an Emergency Medicine Physician at Tampa General Hospital. Her project, titled "Time to Treatment: Characterizing the Current Landscape of Intracranial Hemorrhage Management in Patients on Oral Anticoagulation and the Role of Interfacility Transport Leading to Potential Delays in Care" focused on the current use of a new anticoagulant reversal agent, andexanet-alfa for intracranial hemorrhages.
The research was a retrospective chart review, which gathered information from May 2019-May 2021, and was then analyzed and completed in August 2021. The project was presented at the Florida College of Emergency Physicians annual Symposium By The Sea, alongside other projects conducted by medical students and residents working in emergency departments throughout Florida.
Cassidy Cunningham, OMS-IV, was recently accepted for publication in Academic Emergency Medicine for her group's original research, "A Pilot Study of Prehospital Antibiotics for Severe Sepsis, examining early antibiotic administration by paramedics prior to hospital arrival."
Severe forms of sepsis are major contributors to morbidity and mortality worldwide, and early antibiotic administration decreases mortality rates. The study found accurate paramedic identification of sepsis, low rates of prehospital blood culture contamination, and safety of antibiotic administration, along with significant decreases in time to antibiotic administration. Learn more.
First-year student, Melissa Murphy, recently had research accepted for publication in Cold Spring Harbor Laboratory (CSH) titled, "A Method for Rapid Flow-cytometric Isolation of Endothelial Nuclei and RNA from Archived Frozen Brain Tissue".
Bulk analysis for RNA sequencing approaches have relied on fresh brain tissue digestion sample protocols, which can make donated human analysis difficult to obtain data from.
With our new approach, we can examine RNA expression from abundant archived frozen brain tissues. Utilizing this new technique, our next step is to perform analysis on samples with Frontal Temporal Dementia and Alzheimer's Disease. Learn more.