Research Platforms' Performance Reports TMB 2015-2017 | Page 22

RESEARCH ACTIVITIES
Virus or NP-specific network: Likewise, influenza A virus or NP-specific protein-protein interaction data available from
published literature after data mining and also different databases like VirHostNet has been compiled to generate a more
comprehensive interaction map. The attribute file generated after compiling the NP-host specific interaction data was
loaded on to Cytoscape v 3.5.1 to get a holistic view of the interactions.
Host-virus interactome development: Host interaction data and Np specific protein-protein interaction data was
mapped to generate host-NP (virus) interaction data. This approach has provided a holistic view of Nucleoprotein-host
interactions reported, to date. (Figure 1 and 2).
Figure 1: NP-specific interaction data mapped using
Cytoscape 3.5.1, A. NP specific-human interaction data
(data mining). B. IAV-host interactome data (data mining)
NP highlighted in Orange.
Figure 2: NP-host/ viral interaction
network map
(Blue: Homo sapiens, Red: Influenza A)
(virhostnet 2.0)
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