Ibuprofen Ibuprofen | Page 4

the nitrile, then hydrolyzed to the desired acid: Solubility Ibuprofen is practically insoluble in water, dissolves less than 1 mg of ibuprofen in 1 ml of water (<1 mg / ml). It is soluble in organic solvents such as ethanol or acetone. Adverse effects  Constipation  Diarrhea  Gas or abdominal distension  Dizziness and vomiting  Nervousness  Ringing in the ears More serious effects        Unexplained weight gain Fever Blisters Rash Itch Urticaria Hoarseness