indicated in pediatrics should
always be accompanied by the
corresponding
medical
prescription, regardless of its
presentation and dosage.
Properties
It acts by preventing the
formation of prostaglandins in
the body, which are formed in
response to injuries or certain
diseases that occur with
inflammation and pain.
Synthesis
The synthesis of this compound
is a popular case studied in green
chemistry
(sustainable
chemistry). The original synthesis
of ibuprofen consisted of six
steps, starting with the acylation
of isobutylbenzene by Friedel-
Crafts. Reaction with ethyl
chloroacetate
(Darzens
condensation) gave the α, β-
epoxy
ester,
which
was
decarboxylated and hydrolyzed
to the aldehyde. The reaction
with hydroxylamine gave the
oxime, which was converted to