ESMOLOL – Esmolol Hydrochloride
Esmolol hydrochloride is a beta1-slective adrenergic blocker used to
treat or to prevent tachycardia.
IUPAC name: methyl(RS)-3-{4-[2-hydroxy-3-(propan-2ylamino)propoxy]phenyl}propanoate
Drug class: Beta1-selective adrenergic blocker
Route of administration- Intra venous
Availability – injections 10mg/ml, 250mg/ml
Trade names- Brevibloc
Esmolol blocks beta adrenergic receptors in the heart and
juxtaglomerular apparatus. It reduces the effect of sympathetic
nervous system on heart and kidney tissues and lowers the heart
excitability and cardiac output. It decreases the release of rennin. The
result is lowering of blood pressure and heart rate.
Onset of this drug is less than 5 min. Duration of action is 10-30 min.
Peak of action is 10-20min.
Indications of Esmolol: to treat supraventricular tachycardia, intra
operative & post operative tachycardia and non compensatory
tachycardia