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Ozone Therapy-Historical Origins In 1856, just 16 years after its discovery, ozone was first used in a health care setting to disinfect operating rooms and sterilize surgical instruments. By the end of the 19th century the use of ozone to disinfect drinking water of bacteria and viruses was well established in mainland Europe. In 1892 The Lancet published an article describing the administration of ozone for treatment of tuberculosis. In 1902 another article was published claiming success in treating chronic middle ear deafness with ozone. Ozone was used during the First World War to disinfect wounds. The English medical journal, Lancet, then reported that intravenous infusion Was used successfully to treat pneumonia in the epidemic following World War I. In the 1940's Father Richard Wilhelm, the pioneer in promoting peroxide use, reported on the compound being used extensively to treat everything from bacterial-related mental illness to skin disease and polio.