Forum for Nordic Dermato-Venereology Nr 3, 2018 | Page 10

Anette Bygum – Establishing a Clinical Trial Unit in Dermato-Venereology at Odense University Hospital, Denmark
Contact dermatitis References
Children and adults with suspected contact dermatitis are
examined, patch-tested, and treated at the Allergy Laboratory
and the Eczema Outpatient Clinic. About 500 patients are
tested each year, and among these around 25% have occupa-
tional contact dermatitis. 1. Laurinaviciene R, Sandholdt LH, Bygum A. Drug-induced cuta-
neous lupus erythematosus: 88 new cases. Eur J Dermatol 2017;
27: 28–33.
2. Petersen MP, Moller S, Bygum A, Voss A, Bliddal M. Epidemiology of
cutaneous lupus erythematosus and the associated risk of systemic
lupus erythematosus: a nationwide cohort study in Denmark.
Lupus 2018; 27: 1424–1430.
The Allergy Laboratory offers the service of an Allergen Bank
(www.allergenbanken.dk) from which dermatologist in pri-
vate practice and other dermatology departments, through
subscription, can request extra allergens for patch-testing
individual patients with contact allergens beyond the Euro-
pean baseline series.
Our clinical contact dermatitis research focuses on experimen-
tal contact dermatitis, occupational dermatoses and allergy
to plants in cooperation with Dermatological Investigations
Scandinavia (DIS), a joint CRO between SDU and OUH. DIS
focuses on dermato-toxicological and -allergological studies
on volunteers in cooperation with industry sponsors. DIS
has equipment for non-invasive measuring methods related
to the skin.
References
1. Andersen F, Andersen KH, Bernois A, Brault C, Bruze M, Eudes H,
et al. Reduced content of chloroatranol and atranol in oak moss
absolute significantly reduces the elicitation potential of this fra-
grance material. Contact Dermatitis 2015; 72: 75–83.
2. Mose KF, Burton M, Thomassen M, Andersen F, Kruse TA, Tan Q,
et al. The gene expression and immunohistochemical time-course
of diphenylcyclopropenone-induced contact allergy in healthy
humans following repeated epicutaneous challenges. Exp Dermatol
2017; 26: 926–933.
3. Mose KF, Andersen F, Røpke MA, Skov L, Friedmann PS, Andersen
KE.Anti-inflammatory potency testing of topical corticosteroids
and calcineurin inhibitors in human volunteers sensitized to di-
phenylcyclopropenone. Br J Clin Pharmacol 2018; 84: 1719–1728.
4. Paulsen E, El-Houri RB, Andersen KE, Christensen LP. Parthenolide
in Danish biodynamic and organic milk: A new source of exposure
to an allergenic sesquiterpene lactone. Contact Dermatitis 2018
Jun 20 [Epub ahead of print].
Cutaneous lupus
Since 2007 the department has participated in a European
collaboration on cutaneous lupus erythematosus (EUSCLE),
collecting mostly epidemiological data. As a special interest, we
have a focus on drug-induced lupus describing the changing
pattern of culprit drugs during the last 20 years, finding an
increase in proton pump inhibitor induced SCLE.
We have established a research database with biobank for
future clinical studies.
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U niversity C linics in the N ordic C ountries
Genodermatoses and rare diseases
Our department has a long tradition of clinical handling and
research in genodermatoses, which are often rare diseases.
The area is a rapidly evolving field, not only in diagnostics
with next generation sequencing but also with regards to
orphan drugs.
We are responsible for the national course in genodermatoses
and pediatric dermatology for upcoming dermatologists. A
special focus has been on hereditary hypotrichosis and severe
congenital ichthyosis, with a year-long fruitful collaboration
with colleagues from Bonn and Uppsala. The department is a
member of the European Reference Network for rare diseases,
ERN and participates in the working groups IPK (ichthyosis,
palmoplantar keratoderma) and ALLOCATE (hidrosadenitis
and hereditary angioedema). A European research database
is planned when the legal issues have been solved.
In 2016 a grant from the Danish Dermatologic Society was
donated to a National Research Database on Genodermatoses.
Mostly due to legal obstacles, it is not yet up and running.
Instead we made a regional database with an affiliated biobank,
and as of July 2018 we have included 428 children and adults
with genodermatoses.
References
1. Ü Basmanav FB, Cau L, Tafazzoli A, Méchin MC, Wolf S, Romano
MT, et al. Mutations in three genes encoding proteins involved in
hair shaft formation cause uncombable hair syndrome. Am J Hum
Genet 2016; 99: 1292–1304.
2. Mazereeuw-Hautier J, Hernandez-Martin A, O’Toole EA, Bygum A,
Amaro C, Aldwin M, et al. Management of congenital ichthyoses:
European guidelines of care: Part One. Br J Dermatol 2018 Accepted.
3. Mazereeuw-Hautier J, Hernandez-Martin A, O’Toole EA et al.
Management of congenital ichthyoses: European guidelines of
care: Part Two. Br J Dermatol 2018 Jun 13 [Epub ahead of print].
Hyperhidrosis
A cohort of 400 patients with hyperhidrosis has been estab-
lished and we still recruit for our hyperhidrosis database. In
collaboration with the Danish Hyperhidrosis Organization, a
prospective study is performed to observe symptom patterns,
Forum for Nord Derm Ven 2018, Vol. 23, No. 3
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