Chemwatch: 34-9548
Page 7 of 11
Version No: 4.1.1.1
Issue Date: 02/13/2014
Fido's Flea Shampoo For Cats and Dogs
Hazardous
decomposition
products
Print Date: 06/27/2016
See section 5
SECTION 11 TOXICOLOGICAL INFORMATION
Information on toxicological effects
Inhaled
Ingestion
The material is not thought to produce adverse health effects or irritation of the respiratory tract (as classified by EC
Directives using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that
suitable control measures be used in an occupational setting.
The material has NOT been classified by EC Directives or other classification systems as "harmful by ingestion". This is
because of the lack of corroborating animal or human evidence. The material may still be damaging to the health of the
individual, following ingestion, especially where pre-existing organ (e.g liver, kidney) damage is evident. Present definitions of
harmful or toxic substances are generally based on doses producing mortality rather than those producing morbidity (disease,
ill-health). Gastrointestinal tract discomfort may produce nausea and vomiting. In an occupational setting however, ingestion
of insignificant quantities is not thought to be cause for concern.
Skin Contact
Open cuts, abraded or irritated skin should not be exposed to this material
Entry into the blood-stream through, for example, cuts, abrasions, puncture wounds or lesions, may produce systemic injury
with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably
protected.
Excessive use or prolonged contact may lead to defatting, drying and irritation of sensitive skin
Eye
Limited evidence exists, or practical experience suggests, that the material may cause eye irritation in a substantial number
of individuals and/or is expected to produce significant ocular lesions which are present twenty-four hours or more after
instillation into the eye(s) of experimental animals. Repeated or prolonged eye contact may cause inflammation
characterised by temporary redness (similar to windburn) of the conjunctiva (conjunctivitis); temporary impairment of vision
and/or other transient eye damage/ulceration may occur.
Chronic
Fido's Flea Shampoo
For Cats and Dogs
Limited evidence suggests that repeated or long-term occupational exposure may produce cumulative health effects
involving organs or biochemical systems.
TOXICITY
IRRITATION
Not Available
Not Available
TOXICITY
IRRITATION
dermal (rat) LD50: >7950 mg/kg[2]
piperonyl butoxide
Inhalation (rat) LC50: >5.9 mg/l/4hr
Nil reported
[1]
Oral (rat) LD50: 5630 mg/kg[1]
TOXICITY
pyrethrin I
Oral (rat) LD50: 260 mg/kg
IRRITATION
[2]
TOXICITY
pyrethrin II
Oral (rat) LD50: 200 mg/kg
Nil reported
IRRITATION
[2]
Nil reported
pp 352-355
water
Legend:
PIPERONYL
BUTOXIDE
TOXICITY
IRRITATION
Oral (rat) LD50: >90000 mg/kg[2]
Not Available
1. Value obtained from Europe ECHA Registered Substances - Acute toxicity 2.* Value obtained from manufacturer's SDS.
Unless otherwise specified data extracted from RTECS - Register of Toxic Effect of chemical Substances
The substance is classified by IARC as Group 3:
NOT classifiable as to its carcinogenicity to humans.
Evidence of carcinogenicity may be inadequate or limited in animal testing.
Dermal (rabbit) LD50: >1880 mg/kg [Handbook of Toxicology] *Published value - probably not peer-reviewed ADI: 0.03 mg/kg
PYRETHRIN I
NOTE: Studies with rats and mice indicate rapid oxidation of pyrethrin I. Within 48 hrs. metabolites appear in urine (46%) and
in expired CO2 (0.3%) (1). Some unmetabolised substance is found in faeces (2).
PYRETHRIN II
NOTE: Studies with rats and mice indicate rapid oxidation of pyrethrin II. Within 48 hrs. metabolites appear in urine (7%) and
in expired CO2 (53%) (1). The analogue, pyrethrin I, in contrast, is mostly excreted in urine with a small percentage (0.3%)
found in expired CO2. In common with pyrethrin I unmetabolised substance is found in faeces; some partially metabolised
product is also eliminated in this fashion. (2,3). Pyrethrin II may cause contact allergic dermatitis in those individuals
sensitive to ragweed pollen (3) (3). Gosselin etal; Clinical Toxicology etc. Williams Wilkins