RECENT RESEARCH
an additional 5-day true AA and a 5-day sham AA , respectively . Acute and delayed CINV were assessed by using the MASCC Antiemesis Tool ( MAT ), anticipatory nausea and vomiting were measured by the Index of Nausea , Vomiting , and Retching ( INVR ), and patients ’ quality of life ( QoL ) was evaluated by the Functional Assessment of Cancer Therapy-Breast ( FACT-B ).
Results : Both the true and sham AA groups reported improved CINV outcomes than the standard care group , with the true AA demonstrating larger effects than the sham comparison . The true and sham AA groups had higher complete response ( CR ) rates of CINV when compared with the standard care group , with the difference in the CR of acute CINV achieving statistical significance ( p = 0.03 ). Both the true and sham AA groups demonstrated lower incidence and severity of acute CINV compared with the standard care group with the among-group difference reaching statistical significance for the occurrence ( p = 0.04 ) and severity ( p = 0.001 ) of acute nausea . No significant differences in anticipatory CINV and QoL were found among the groups .
Conclusion : The use of AA plus standard antiemetic treatment and care was superior to the use of standard antiemetic treatment and care alone in managing CINV among BC patients receiving chemotherapy . The antiemetic effects of AA were identified to be more profound in improving acute CINV , particularly acute nausea . The antiemetic effects of AA were deemed to be a mixture of specific treatment effects and placebo effects , and the placebo effects were very large and even reached clinical significance .
Lee B , Kim BK , Kim M . et al .
Electroacupuncture for treating cancerrelated insomnia : a multicenter , assessorblinded , randomized controlled , pilot clinical trial . BMC Complement Med Ther . 2022 ; 22 , 77 . https :// doi . org / 10.1186 / s12906-022-03561-w
Background : Insomnia is one of the most frequent symptoms in people with cancer . Electroacupuncture has been widely used in people with cancer or insomnia . We explored the feasibility and preliminary effectiveness of electroacupuncture for cancer-related insomnia .
Methods : People with cancer and insomnia disorder were randomly allocated to electroacupuncture , shamelectroacupuncture , or usual care groups . Participants received either 10 sessions of electroacupuncture at real acupoints , sham-electroacupuncture at non-acupoints , or usual care in each group for 4 weeks . We calculated the recruitment , adherence , and completion rates of participants . The Insomnia Severity Index ( ISI ), Pittsburgh Sleep Quality Index ( PSQI ), sleep diary and actigraphy-derived sleep parameters , Functional Assessment of Cancer Therapy- Fatigue ( FACT-F ), Montreal Cognitive Assessment ( MoCA ), and salivary levels of cortisol and melatonin were evaluated as outcome measures .
Results : Twenty-two participants were enrolled ( 8 , 6 , and 8 respectively in the electroacupuncture , shamelectroacupuncture , and usual care groups ) and 20 participants completed the trials ( 8 , 4 , and 8 respectively ). The recruitment , adherence , and completion rates were 78.57 % ( 22 / 28 ), 95.45 % ( 21 / 22 ), and 90.91 % ( 20 / 22 ), respectively . Most of the participants had previously received conventional treatment for insomnia , but few had received Korean medicine treatment , without any demographic or clinical differences between groups . In the electroacupuncture group , there was a statistically significant reduction of 10.13 ( mean ) ± 8.15 ( standard deviation ) and 5 ± 3.70 points in mean ISI and PSQI scores at 4 weeks post-treatment ( P = . 0098 and . 0066 ), compared with sham-electroacupuncture ( 2.06 ± 7.15 and 1.61 ± 4.34 ; P = . 4796 and . 3632 ) and usual care ( 3.25 ± 2.60 and 1.38 ± 2.13 ; P = . 0096 and . 1112 ). Although there was no significant difference in ISI score between groups at 4 weeks posttreatment , the electroacupuncture group continued to improve significantly at 4 weeks ’ follow-up , showing borderline and significant differences compared to the sham-electroacupuncture and usual care ( P = . 0614 and . 0015 ). The FACT-F scores in electroacupuncture group showed a significant improvement compared with the sham-electroacupuncture group ( P = . 0305 ). No electroacupuncture-related adverse events were reported .
Conclusions : Electroacupuncture might be feasible for cancer-related insomnia , despite slow participant recruitment . Additional trials with adequately powered sample sizes and a substantial change to the recruitment procedure are needed .
Aromatherapy
Horváth A , Pandur E , Sipos K , Micalizzi G , Mondello L , Böszörményi A , Birinyi P , Horváth G .
Anti-inflammatory effects of lavender and eucalyptus essential oils on the in vitro cell culture model of bladder pain syndrome using T24 cells . BMC Complementary Medicine and Therapies , 2022 ; 22 , rticle number : 119 .
Background : Interstitial cystitis ( IC ) has a chronic chemical irritation and inflammation of non-bacterial origin in the bladder wall leading to various severe symptoms . There is evidence that chronic inflammation is significantly associated with abnormal urothelial barrier function , epithelial dysfunction . This is the underlying cause of urothelial apoptosis and sterile inflammation .
Method : The anti-inflammatory effects of lavender and eucalyptus essential oils ( EOs ) and their main components ( linalool and eucalyptol ) were investigated in the T24 human bladder epithelial cell line on TNFα stimulated inflammation , at 3 types of treatment schedule . The mRNA of proinflammatory cytokines ( IL-1β , IL-6 , IL-8 ) were measured by Real Time PCR . Human IL-8 ELISA measurement was performed as well at 3 types of treatment schedule . The effects of lavender and eucalyptus EOs and their main components were compared to the response to NFκB inhibitor ACHP ( 2-amino-6- [ 2- ( cyclopropylmethoxy ) - 6-hydroxyphenyl ] -4- ( 4-piperidinyl ) -3- pyridinecarbonitrile ).
Result : There is no significant difference statistically , but measurements show that lavender EOs are more effective than eucalyptus EO . Long time treatment
104 | vol28 | no2 | JATMS