Volume: 1
Número: 2
outubro 2019
Utilização de compostos com atividade antimalárica
no controlo de perkinsiose em bivalves
Autores:
Lília I. L. Cabral, Catarina Dias, Ricardo B. Leite e Maria L. S. Cristiano
Afilições:
Centro de Ciências do Mar (CCMar), UAlg,
Departamento de Química e Farmácia, Faculdade de Ciências e Tecnologia, UAlg
Instituto Gulbenkian de Ciência
Revisão:
Escola: ES Pinheiro e Rosa, Faro
Alunos: Catalina Botnaru, Diogo Lourenço, Inês Borges, Janine Ferro, Luena Marques, Maximilian
Kaiser, Pedro Jesus, Rodrigo Fernandes, Rúben Gonçalves e Sofia Ramalho
ABSTRACT:
Outbreaks of protozoan agents such as Perkinsus olseni represent major losses for
the shellfish producers, urging the development of measures to contain and decrease
these episodes. Antimalarial drugs and selective inhibitors designed to target unique
metabolic features of the parasite (metabolisms that are not replicated in the host,
such as the folate, and shikimate pathways), have been successfully used in the
laboratory to inhibit Perkinsus proliferation.
However, due to specificities in Perkinsus species and the surrounding environment,
development of drug candidates requires further optimization at the molecular level,
to improve pharmacologic properties, as well as development of suitable tests and
administration protocols for adequate use. Recent advances and future perspectives
on the use endoperoxide-type antimalarials for perkinsosis therapy are presented and
discussed.
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