The Leaf THE LEAF March-April 2019 | Page 25

to the Arthritis Society in order to help foot the bill for Dr. McDougall’s research. When the market is bullish on new research, it’s a good sign for sufferers. The reality is that cannabinoid receptors play a crucial role in the regulating the body’s immune system. What’s not clear is exactly how they operate. From a strictly biological perspective, auto- immune disorders like rheumatoid arthritis, and chronic disorders like osteoarthritis don’t make much sense. Why would the body attack itself or be unable repair such crucial functions, like joint dexterity? The discovery of cannabinoid receptors at inflammatory sites may provide an answer. Thanks to a litany of previous works in this arena, McDougall’s team already knows that cannabis-based medicines act directly on CB2 sites and suppress inflammation and pain by mediating immune responses at the sites of inflammation. This suggests that the body’s reaching out for molecules to help it reconstruct its vital elements. The next step will be to see if changes to the medicine create different responses in the body. If researchers can discover new ways in which cannabinoid receptors take up or use medicines, it could open a window of treatment possibilities. So much of our current knowledge is in the theoretical sphere, with most doctors and patients simply thankful for effective pain treatment—whether it’s understood or not is a secondary concern. However, as our knowledge of the body’s endocannabinoid system grows, and we look further into the means by which cannabis- based medicines reduce inflammation and affect nerves, we’re likely to discover novel ways of treatment—and possible ways to reverse the long-lasting joint damage of arthritis. While McDougall’s research has yet to be completed, the results are expected soon. ehealthdigest.org/2018/10/28/cannabis- could-be-reversing-damage-to-arthritic- joints/