1/20th of a grain is 3.24mgs
“No immediate effect was perceptible, and in
an hour and a half two drops more were given.
The infant fell asleep in a few minutes, and
slept soundly till 4pm, when she awoke,
screamed for food, took the breast freely, and
fell asleep again.
At 9am, 1st of October, I found the child fast
asleep, but easily roused; the pulse,
countenance, and skin perfectly natural.
In this drowsy state she continued for four
days totally free from convulsive symptoms
in any form.
Dr WB O’Shaughnessy
Case of Infantile Convulsions, 1843
“A very interesting case of this disease has
recently occurred in my private practice, the
particulars of which I have the permission of
the family to insert in this paper.
A female infant, forty days old, the child of
Mr. and Mrs. J. L., of Calcutta, on the 10th of
September had a slight attack of convulsions,
which recurred chiefly at night for about a
fortnight, and for which the usual purgatives-
warm baths and a few doses of calomel and
chalk-were given without effect. On that day
the attacks were almost unceasing, and
amounted to regular tetanic paroxysms.
The child had, moreover, completely lost
appetite and was emaciating rapidly”
“I had by this time exhausted all the usual
methods of treatment, and the child was
apparently in a blinking state.
Under these circumstances I stated to the
parents the results of the experiments I had
made with the hemp, and my conviction that
it would relieve their infant if relief could
possibly be obtained.
They gladly consented to the trial, and a single
drop of the spirituous tincture, equal to the
one-twentieth part of a grain in weight, was
placed on the child’s tongue at 10pm.”
“During this time the bowels were frequently
spontaneously relieved, and the appetite
returned to the natural degree.
October 4th, At 1am, convulsions returned
and continued at intervals during the day; 5
drop doses of the tincture were given hourly.
Up to midnight there were 30 fits, and 44
drops of the tincture of hemp were
ineffectually given.”
“Paroxysms continued during the night.
At 11am, it was found that the tincture in use
during the preceding days had been kept by
the servant in a small bottle with a paper
stopper, the spirit had evaporated and the
whole of the resin had settled on the sides of
the phial.
The infant had in fact been taking drops of
mere water during the preceding day.”
Always shake cannabis preparations before
use and store in the fridge.
“A new preparation was given in 3 drop doses
during the 5th and 6th, and increased to 8
drops with the effect of diminishing the
violence, though not of preventing the return
of the paroxysm.
On the 7th I met Dr. Nicholson in
consultation, and despairing of a cure from
the hemp, it was agreed to intermit its use, to
apply a mustard poultice to the epigastrium,
and to give a dose of castor oil and
turpentine.”