A . J . Whelan et al .: J Extra Corpor Technol 2024 , 56 , 167 – 173 173
oxygenation circuit : results from an ex vivo study . Crit Care . 2015 ; 19 ( 1 ): 164 . https :// doi . org / 10.1186 / s13054-015-0891-z .
27 . Mehta NM , Halwick DR , Dodson BL , Thompson JE , Arnold JH . Potential drug sequestration during extracorporeal membrane oxygenation : results from an ex vivo experiment . Intensive Care Med . 2007 ; 33 ( 6 ): 1018 – 1024 . https :// doi . org / 10.1007 / s00134-007-0606-2 .
28 . Dallefeld SH , Sherwin J , Zimmerman KO , Watt KM . Dexmedetomidine extraction by the extracorporeal membrane oxygenation circuit : results from an in vitro study . Perfusion . 2020 ; 35 ( 3 ): 209 – 216 . https :// doi . org / 10.1177 / 0267659119868062 .
29 . Preston TJ , Ratliff TM , Gomez D , et al . Modified surface coatings and their effect on drug adsorption within the extracorporeal life support circuit . J Extra Corpor Technol . 2010 ; 42 ( 3 ): 199 – 202 .
30 . Green DJ , Watt KM , Fish DN , McKnite A , Kelley W , Bensimhon AR . Cefepime extraction by extracorporeal life support circuits . J Extra Corpor Technol . 2022 ; 54 ( 3 ): 212 – 222 . https :// doi . org / 10.1182 / ject-212-222 .
31 . Imburgia CE , Rower JE , Green DJ , et al . Remdesivir and GS- 441524 extraction by ex vivo extracorporeal life support circuits . ASAIO J . 2022 ; 68 ( 9 ): 1204 – 1210 . https :// doi . org / 10.1097 / MAT . 0000000000001616 .
32 . Onichimowski D , Nosek K , Ziółkowski H , Jaroszewski J , Pawlos A , Czuczwar M . Adsorption of vancomycin , gentamycin , ciprofloxacin and tygecycline on the filters in continuous renal replacement therapy circuits : in full blood in vitro study . J Artif Organs . 2021 ; 24 ( 1 ): 65 – 73 . https :// doi . org / 10.1007 / s10047-020-01214-8 .
33 . Onichimowski D , Ziółkowski H , Nosek K , Jaroszewski J , Rypulak E , Czuczwar M . Comparison of adsorption of selected antibiotics on the filters in continuous renal replacement therapy circuits : in vitro studies . J Artif Organs . 2020 ; 23 ( 2 ): 163 – 170 . https :// doi . org / 10.1007 / s10047-019-01139-x .
34 . Kumar A , Mann HJ , Keshtgarpour M , et al . In vitro characterization of oritavancin clearance from human blood by low-flux , high-flux , and continuous renal replacement therapy dialyzers . Int J Artif Organs . 2011 ; 34 ( 11 ): 1067 – 1074 . https :// doi . org / 10.5301 / ijao . 5000008 .
35 . Baud FJ , Houzé P , Raphalen JH , et al . Diafiltration flowrate is a determinant of the extent of adsorption of amikacin in renal replacement therapy using the ST150 Ò -AN69 filter : An in vitro study . Int J Artif Organs . 2020 ; 43 ( 12 ): 758 – 766 . https :// doi . org / 10.1177 / 0391398820911928 .
36 . Choi G , Gomersall CD , Lipman J , et al . The effect of adsorption , filter material and point of dilution on antibiotic elimination by haemofiltration an in vitro study of levofloxacin . Int J Antimicrob Agents . 2004 ; 24 ( 5 ): 468 – 472 . https :// doi . org / 10.1016 / j . ijantimicag . 2004.06.005 .
37 . Wildschut ED , Ahsman MJ , Allegaert K , Mathot RAA , Tibboel D . Determinants of drug absorption in different ECMO circuits . Intensive Care Med . 2010 ; 36 ( 12 ): 2109 – 2116 . https :// doi . org / 10.1007 / s00134-010-2041-z .
38 . Gist KM , Mizuno T , Goldstein SL , Vinks A . Retrospective evaluation of milrinone pharmacokinetics in children with kidney injury . Ther Drug Monit . 2015 ; 37 ( 6 ): 792 – 796 . https :// doi . org / 10.1097 / FTD . 0000000000000214 .
39 . O ’ Hanlon CJ , Sumpter A , Anderson BJ , Hannam JA . Timevarying clearance in milrinone pharmacokinetics from premature neonates to adolescents . Clin Pharmacokinet . 2024 ; 63:695 – 706 . https :// doi . org / 10.1007 / s40262-024-01372-5 .
40 . Taniguchi T , Shibata K , Saito S , Matsumoto H , Okeie K . Pharmacokinetics of milrinone in patients with congestive heart failure during continuous venovenous hemofiltration . Intensive Care Med . 2000 ; 26 ( 8 ): 1089 – 1093 . https :// doi . org / 10.1007 / s001340051322 .
41 . Watt KM , Cohen-Wolkowiez M , Barrett JS , et al . Physiologically based pharmacokinetic approach to determine dosing on extracorporeal life support : fluconazole in children on ECMO . CPT Pharmacometrics Syst Pharmacol . 2018 ; 7 ( 10 ): 629 – 637 . https :// doi . org / 10.1002 / psp4.12338 .
Cite this article as : Whelan AJ , Mim S , Hunt JP , McKnite AM , Green DJ , Imburgia CE , Momper JD , Stitt G & Watt KM . Interaction of milrinone with extracorporeal life support . J Extra Corpor Technol 2024 , 56 , 167 – 173 . https :// doi . org / 10.1051 / ject / 2024014 .