172 A . J . Whelan et al .: J Extra Corpor Technol 2024 , 56 , 167 – 173
KW analyzed the data . AW , SH , JH , AM , DG , JM , GS , and KW drafted and finalized the manuscript . All authors approved the final version of the manuscript .
Ethics approval
This study was IRB exempt because it did not include any human subjects .
Supplementary material
The supplementary material of this article is available at https :// ject . edpsciences . org / 10.1051 / ject / 2024014 / olm .
Supplementary Table 1 : Milrinone control plasma concentration ( ng / mL ).
Supplementary Table 2 : Milrinone ECMO plasma concentration ( ng / mL ).
Supplementary Table 3 : Milrinone CRRT plasma concentrations ( ng / mL ).
References
1 . Hayes LW , Oster RA , Tofil NM , Tolwani AJ . Outcomes of critically ill children requiring continuous renal replacement therapy . J Crit Care . 2009 ; 24 ( 3 ): 394 – 400 . https :// doi . org / 10 . 1016 / j . jcrc . 2008.12.017 .
2 . Tandukar S , Palevsky PM . Continuous renal replacement therapy : who , when , why , and how . Chest . 2019 ; 155 ( 3 ): 626 – 638 . https :// doi . org / 10.1016 / j . chest . 2018.09.004 .
3 . Hoffman TM , Wernovsky G , Atz AM , et al . Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease . Circulation . 2003 ; 107 ( 7 ): 996 – 1002 . https :// doi . org / 10.1161 / 01 . CIR . 0000051365.81920.28 .
4 . Vogt W , Läer S . Prevention for pediatric low cardiac output syndrome : results from the European survey EuLoCOS-Paed . Pediatr Anesth . 2011 ; 21 ( 12 ): 1176 – 1184 . https :// doi . org / 10.1111 / j . 1460-9592.2011.03683 . x .
5 . Hornik CP , Yogev R , Mourani PM , et al . Population pharmacokinetics of milrinone in infants , children , and adolescents . J Clin Pharmacol . 2019 ; 59 ( 12 ): 1606 – 1619 . https :// doi . org / 10.1002 / jcph . 1499 .
6 . Fredholm M , Jörgensen K , Houltz E , Ricksten SE . Inotropic and lusitropic effects of levosimendan and milrinone assessed by strain echocardiography – a randomised trial . Acta Anaesthesiol Scand . 2018 ; 62 ( 9 ): 1246 – 1254 . https :// doi . org / 10.1111 / aas . 13170 .
7 . Yano M , Kohno M , Ohkusa T , et al . Effect of milrinone on left ventricular relaxation and Ca 2þ uptake function of cardiac sarcoplasmic reticulum . Am J Physiol Heart Circ Physiol . 2000 ; 279 ( 4 ): H1898 – H1905 . https :// doi . org / 10.1152 / ajpheart . 2000.279.4 . H1898 .
8 . Honerjäger P , Nawrath H . Pharmacology of bipyridine phosphodiesterase III inhibitors . Eur J Anaesthesiol Suppl . 1992 ; 5:7 – 14 .
9 . Kim M , Seong SW , Song PS , et al . Inodilators may improve the in-hospital mortality of patients with cardiogenic shock undergoing veno-arterial extracorporeal membrane oxygenation . J Clin Med . 2022 ; 11 ( 17 ): 4958 . https :// doi . org / 10.3390 / jcm11174958 .
10 . Rodenas-Alesina E , Luis Scolari F , Wang VN , et al . Improved mortality and haemodynamics with milrinone in cardiogenic shock due to acute decompensated heart failure . ESC Heart Fail . 2023 ; 10 ( 4 ): 2577 – 2587 . https :// doi . org / 10.1002 / ehf2.14379 .
11 . Ricci Z , Goldstein SL . Pediatric continuous renal replacement therapy . Contrib Nephrol . 2016 ; 187:121 – 130 . https :// doi . org / 10.1159 / 000442370 .
12 . Watson RS , Crow SS , Hartman ME , Lacroix J , Odetola FO . Epidemiology and outcomes of pediatric multiple organ dysfunction syndrome . Pediatr Crit Care Med . 2017 ; 18 ( 3 _ suppl Suppl 1 ): 4 – 16 . https :// doi . org / 10.1097 / PCC . 0000000000001047 .
13 . Nasr VG , Raman L , Barbaro RP , et al . Highlights from the Extracorporeal Life Support Organization Registry : 2006 – 2017 . ASAIO J . 2019 ; 65 ( 6 ): 537 – 544 . https :// doi . org / 10.1097 / MAT . 0000000000000863 .
14 . Raffaeli G , Pokorna P , Allegaert K , et al . Drug disposition and pharmacotherapy in neonatal ECMO : from fragmented data to integrated knowledge . Front Pediatr . 2019 ; 7:360 . https :// doi . org / 10.3389 / fped . 2019.00360 .
15 . Nolin TD , Aronoff GR , Fissell WH , et al . Pharmacokinetic assessment in patients receiving continuous RRT : perspectives from the kidney health initiative . Clin J Am Soc Nephrol . 2015 ; 10 ( 1 ): 159 – 164 . https :// doi . org / 10.2215 / CJN . 05630614 .
16 . Hunt JP , McKnite AM , Green DJ , Whelan AJ , Imburgia CE , Watt KM . Interaction of ceftazidime and clindamycin with extracorporeal life support . J Infect Chemother . 2023 ; 29 ( 12 ): 1119 – 1125 . https :// doi . org / 10.1016 / j . jiac . 2023.08.007 .
17 . Burkhardt BE , Rücker G , Stiller B . Prophylactic milrinone for the prevention of low cardiac output syndrome and mortality in children undergoing surgery for congenital heart disease . Cochrane Database Syst Rev . 2015 ; 3 : CD00951 . https :// doi . org / 10.1002 / 14651858 . CD009515 . pub2 .
18 . Bishara T , Seto WTW , Trope A , Parshuram CS . Use of milrinone in critically ill children . Can J Hosp Pharm . 2010 ; 63 ( 6 ): 420 – 428 . https :// doi . org / 10.4212 / cjhp . v63i6.960 .
19 . DrugBank Version 45.1.1 . Drug and drug target database . http :// www . drugbank . ca . Accessed 26 Aug 2023 .
20 . Cone J , Wang S , Tandon N , et al . Comparison of the effects of cilostazol and milrinone on intracellular cAMP levels and cellular function in platelets and cardiac cells . J Cardiovasc Pharmacol . 1999 ; 34 ( 4 ): 497 – 504 . https :// doi . org / 10.1097 / 00005344- 199910000-00004 .
21 . Kuthe A , Magert H , Uckert S , Forssmann WG , Stief CG , Jonas U . Gene expression of the phosphodiesterases 3A and 5A in human corpus cavernosum penis . Eur Urol . 2000 ; 38 ( 1 ): 108 – 114 . https :// doi . org / 10.1159 / 000020262 .
22 . Baruch L , Patacsil P , Hameed A , Pina I , Loh E . Pharmacodynamic effects of milrinone with and without a bolus loading infusion . Am Heart J . 2001 ; 141 ( 2 ): 14A – 21A . https :// doi . org / 10.1067 / mhj . 2001.111404 .
23 . Bailey JM , Levy JH , Kikura M , Szlam F , Hug CC . Pharmacokinetics of intravenous milrinone in patients undergoing cardiac surgery . Anesthesiology . 1994 ; 81 ( 3 ): 616 – 622 . https :// doi . org / 10.1097 / 00000542-199409000-00014 .
24 . Cox ZL , Calcutt MW , Morrison TB , Akers WS , Davis MB , Lenihan DJ . Elevation of plasma milrinone concentrations in stage D heart failure associated with renal dysfunction . J Cardiovasc Pharmacol Ther . 2013 ; 18 ( 5 ): 433 – 438 . https :// doi . org / 10.1177 / 1074248413489773 .
25 . Lemaitre F , Hasni N , Leprince P , et al . Propofol , midazolam , vancomycin and cyclosporine therapeutic drug monitoring in extracorporeal membrane oxygenation circuits primed with whole human blood . Crit Care . 2015 ; 19:40 . https :// doi . org / 10.1186 / s13054-015-0772-5 .
26 . Shekar K , Roberts JA , Mcdonald CI , et al . Protein-bound drugs are prone to sequestration in the extracorporeal membrane