50 N . Jabayeva et al .: J Extra Corpor Technol 2024 , 56 , 45 – 54
Figure 2 . Continued .
In our study , we found that the use of blood purification adsorbers during and after surgery with cardiopulmonary bypass was associated with a reduction of IL-6 , CRP , and leucocytes . CRP levels showed lower levels through three days in the HA 330 group .
Studies have shown that a longer duration of cardiopulmonary bypass has a negative impact on the time of recovery following surgery with CPB [ 23 , 24 ]. Many factors might be involved in delayed recovery following cardiopulmonary bypass , though the exact mechanism is unknown . In our series half of the patients had advanced valvular disease , one-third had aortic pathology and one-quarter were reoperated . The influence of HA should be evaluated in these subgroups separately in larger studies as they may have more patient-related risk factors for end organ failure . In addition , we evaluated only patients with long duration of cardiopulmonary bypass , hoping that the extracorporeal blood purification therapy might be of utmost importance in reducing the negative impact of