N . Jabayeva et al .: J Extra Corpor Technol 2024 , 56 , 45 – 54 49
Figure 2 . Cytokines and secondary outcome measures ( a , b , c , d ).
technologies with different types of adsorbents have been used and evaluated in various critical diseases [ 15 – 19 ], having been shown to be safe and effective , significantly improving hemodynamics and reducing the catecholamine requirement . Data for the use of this technology in patients undergoing cardiac surgery with cardio-pulmonary bypass remains scarce .
In a series of 16 cardiac surgery patients with systemic inflammatory response syndrome after CPB and following AKI , Träger et al . [ 20 ] reported that haemosorption treatment can decrease elevated cytokine levels ( IL-6 and IL-8 ), stabilize impaired hemodynamics , and improve organ function . In a further study of 39 cardiac surgery patients with acute infective endocarditis who underwent valve replacement , Träger et al . [ 21 ] also demonstrated that haemosorption therapy may reduce the postoperative response of pivotal cytokines level , clinical parameters , and the requirement for vasopressors , improving hemodynamic stability and functional improvement of organ . Likewise , Nemeth et al . [ 22 ] reported that intraoperative hemoperfusion treatment was associated with a decreased need for vasopressors in patients undergoing heart transplantation .