The Journal of ExtraCorporeal Technology Issue 55-1 | Page 44

36 J . Blanco-Morillo et al .: J Extra Corpor Technol 2023 , 55 , 30 – 38
Table 3 . Average treatment effect on treated ( percentual estimation ).
Variate
HG Mean
CG Mean
ATT
95 % CI
p-Value
MecV > 10
12.62
26.51
�13.89
�23.68
�4.10
0.01 *
ICU > 2
31.19
47.47
�16.28
�27.13
�5.43
0.00 *
Pulm Comp
5.50
8.70
�3.20
�9.43
3.03
0.31
Card Comp
0.92
1.59
�0.68
�3.14
1.79
0.59
Neur Comp
5.96
10.34
�4.37
�11.39
2.65
0.18
Glob Comp
1.38
5.68
�4.31
�9.03
0.41
0.07
Bleeding > 400
48.94
57.64
�8.70
�20.45
3.05
0.15
Exitus
5.50
12.71
�7.21
�14.61
0.19
0.06
RBC24
5.05
52.60
�47.55
�57.27
�37.83
0.00 *
RBC > 24
4.59
38.55
�33.96
�43.08
�24.84
0.00 *
FP24
0.92
11.22
�10.31
�15.75
�4.87
0.00 *
FP > 24
0.46
4.45
�3.99
�7.76
�0.23
0.04 *
PT24
3.21
32.07
�28.86
�37.48
�20.23
0.00 *
PT > 24
0.92
4.93
�4.01
�8.37
0.35
0.07
GlobalBP
6.88
66.75
�59.87
�69.27
�50.47
0.00 *
Abbreviations : MecV > 10 = Mechanical ventilation longer than 10 h ; ICU > 2 = Intensive care unit stay longer than 2 days ; Pulm . Comp . = Pulmonary complication ; Card . Comp . = Cardiologic complications ; Neur . Comp . = Neurologic complications ; Glob . Comp . = Multiorganic failure ; Bleeding > 400 = Drainage blood loss > 400 mL within the first 24 hours ; Exitus = survival ; RBC24 = Red Blood Cell Transfusion the Day of Surgery ; RBC > 24 = Red Blood Cell Transfusion after the Day of Surgery to Discharge ; FP > 24 = Frozen plasma Transfusion on the Day of Surgery ; FP > 24 = Frozen Plasma Transfusion after the Day of Surgery to Discharge ; PT24 = Platelets Cell Transfusion on the Day of Surgery ; PT > 24 = Platelets Transfusion after Day of Surgery to Discharge , GlobalBP : Exposure to any blood product until discharge . Results correspond to 2000 iterations of bootstrap . Cases showed as p-value = 0.00 presented a * p-value < 0.05 .
Table 4 . Minimum direct cost estimation .
Unitary cost
Price ($)
Time
ATT
Cost / patient ($)
RBC transfusion *
230.59
24 hours
�47.55 %
�109.64
> 24 h – discharge
�33.96 %
�78.31
PT transfusion *
531.56
24 h
�28.86 %
�153.51
FP transfusion *
201.72
24 h
�10.31 %
�20.78
> 24 h – discharge
�3.99 %
�8.04
Daily ICU stay
1299.33
�16.28 %
�211.57
HAR application
0
0.00
Total amount
�581.70
Abbreviations : ATT : Average treatment effect on treated , RBC : Red Blood Cells ; PT : platelets ; FP : Fresh plasma ; HAR : Hematic Antegrade Repriming ; HCU : High Care Unit ; ICU : Intensive Care Unit . * Includes transfusional fix expenses . Prices obtained from : [ 15 ].
Table 5 . Minimum global cost estimation .
Unitary cost *
Price ($)
Period
ATT
Cost / patient ($)
RBC transfusion
1183.22
24 h
�47.55 %
�562.62
> 24 h to discharge
�33.96 %
�401.82
PT transfusion
3457.06
24 h
�28.86 %
�977.71
FP transfusion
1608.37
24 h
�10.31 %
�165.82
> 24 h to discharge
�3.99 %
�64.17
ICU > 2d
3500
�16.28 %
�569.80
HAR application
0
0
Total amount
�2741.94
Abbreviations : ATT : Average treatment effect on treated , RBC : red blood cells , PT : platelets , FP : fresh plasma , ICU > 2d : intensive care unit costs after the 2nd day of stay . * Overall cost per process was obtained from [ 36 – 39 ].
assessing retrospective samples , the results are affected by a higher model dependency than when a prospective randomized methodology is applied [ 40 ].
The exclusion criteria applied may have led to the underestimation of certain outcome variables . While the elimination of cases with clinical records compliant with criteria may have