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R EFERENCES r 49 Xu Y, Ku B et al. Curcumin reverses impaired hippocampal neurogenesis and increases serotonin receptor 1A mRNA and brain-derived neurotrophic factor expression in chron- ically stressed rats. Brain Res. 2007 Aug 8;1162:9–18. Epub 2007 Jun 21. Lim GP, Chu T et al. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci. 2001 Nov 1; 21(21):8370–77. Chapter 7 Bundy R, et al. Turmeric extract may improve irritable bowel syndrome symptomology in otherwise healthy adults: a pilot study. J Altern Complement Med. 2004 Dec;10(6): 1015–18. Kawamori T, et al. Chemopreventive effect of curcumin, a naturally occurring anti-inflam- matory agent, during the promotion/progression stages of colon cancer. Cancer Res. 1999;59:597–601. Chapter 8 Uysal KT, Wiesbrock SM et al. Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature. 1997, 389:610–614. Leray V, Freuchet B et al. Effect of citrus polyphenol and curcumin-supplemented diet on inflammatory state in obese cats. Br J Nutr. 2011 Oct;106 Suppl 1:S198–201.] Lago F Dieguez C et al. Adipokines as emerging mediators of immune response and inflammation. Nat Clin Pract Rhematoll. 2007 3:716–724. Awasthi S, Srivatava SK, Piper JT, Singhal SS, Chaubey M, Awasthi YC. Curcumin pro- tects against 4-hydroxy-2-trans-nonenal-induced cataract formation in rat lenses. Am J Clin Nutr. 1996 Nov;64(5):761–766. Rai D, Yadav D et al. Design and development of curcumin bioconjugates as antiviral agents. Nucleic Acids Symp Ser (Oxf). 2008;(52):599–600. Bright JJ. Curcumin and autoimmune disease. Adv Exp Med Biol. 2007; 595: 425–451. Chapter 9 Benny M, Antony B. Bioavailability of BioCurcumax™ (BCM-95 ® ). Spice India. Septem- ber, 2006:11–15. Merina B, Iyer VS, et al. A pilot cross-over study to evaluate human oral bioavailability of BCM-95CG (Biocurcumax), a novel bioenhanced preparation of curcumin. Ind J Pharm Sci. 2008;70(4):445–449. Poster presentation. Oral Bioavailability of BCM-95 ® Curcumin in Dogs. 2009 ACVIM Forum/Canadian VMA Convention: June 3–6, 2009; Montréal, Québec, Canada.] Antony B, Merina B et al. A pilot cross-over study to evaluate human oral bioavailabili- ty of BCM-95 ® CG (Biocurcumax) a novel bioenhanced preparation of curcumin. Ind J Pharm Sci. 2008;70(4):445–450. Bhardwaj R, Glaeser H et al. Piperine, a Major Constituent of Black Pepper, Inhibits Human P-glycoprotein and CYP3A4. The Journal of Pharmacology and Experimental Therapeutics. 2002 Aug;302(2):645–650.