COSMETICS & PERSONAL CARE science with dermatological performance, offering consumers a new way to feel good and look radiant, without the need of romance.
Science behind GlowCytocin
Oxytocin, often referred to as the‘ love molecule’, is best known for its role in social bonding, emotional wellbeing and stress reduction. However, recent research has uncovered its significant effects on skin physiology.
Figure 1- Protective effect of GlowCytocin on sensory neurons exposed to capsaicin
Figure 2- Stimulating effects of GlowCytocin on axonal density
Oxytocin receptors( OXTRs) are present in various skin cells, including fibroblasts and sensory neurons, where they play a crucial role in skin regeneration, sensory perception and irritation control. High oxytocin levels have been linked to increased cell proliferation and enhanced skin elasticity. Oxytocin also influences the nervous system’ s response to touch, making the skin more receptive
to pleasant sensations while reducing discomfort.
GlowCytocin harnesses the benefits of oxytocin by stimulating its receptors in the skin, leading to a cascade of rejuvenating and soothing effects that in the end confer a radiant‘ love glow’. It works through a multimodal mechanism that enhances fibroblast proliferation, increases receptiveness to pleasurable touch and reduces skin discomfort.
To validate this mechanism of action, in vitro and ex vivo studies have been conducted. Tests on epithelial cells expressing human oxytocin receptors showed that GlowCytocin significantly stimulates OXTR activation in a dose-dependent manner, thus mimicking the effects of natural oxytocin in the skin. This activation is a key trigger for the ingredient’ s rejuvenating and sensory-enhancing properties.
On dermal fibroblast cultures, GlowCytocin demonstrated a 79 % increase in fibroblast proliferation. This supports its ability to enhance skin renewal, improve elasticity, and reduce the appearance of wrinkles. When tested on sensory neuron cultures under capsaicin-stress conditions, GlowCytocin increased sensory neuron proliferation by 89 % and reduced nociceptive( pain-related) CGRP release by 26 %, confirming its ability to boost skin’ s sensory perception while reducing discomfort( Figure 1).
To complete these studies, organon-chip models were used to show the ability of the product to control neuronal activities. On nociceptive neurons exposed to capsaicin, GlowCytocin inhibited capsaicininduced neuronal electrical activity by 43 %, for a soothing effect. On sensory neurons, this test showed that GlowCytocin improves axonal density by 211 % for enhanced sensoriality( Figure 2).
Achieving the‘ love glow’ effect
Through clinical studies, GlowCytocin has been proven to create a skin-mind
SEP / OCT 2025 SPECCHEMONLINE. COM
59