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Viral Immunology and Autoimmunity
My research investigates fundamental mechanisms of innate immunity, focusing on how the immune system distinguishes self from non-self in infection and autoimmunity. We study nucleic acid sensors that detect pathogenic DNA or RNA, defining their molecular activation pathways and functional roles in health and disease.
Dr Ng Chen Seng ng. chenseng @ monash. edu
Lecturer
Expertise
Expertise Innate immunity Public Autoimmunity health Education
Virology Financial statistics
Achievement / Award Recipient of the International Brain Research Organization( IBRO) Associate School for Asia Pacific Region( 2025) Rising Star Award by IBRO( 2023) ALS Canada-Brain Canada
Discovery Award( 2022)
My group also examines host restriction factors, antiviral proteins that block viral replication and the strategies viruses use to evade or antagonize these defences, reflecting an ongoing evolutionary arms race.
In parallel, we explore how failures in immune regulation lead to autoimmunity, where self-antigens are misrecognized, triggering chronic inflammation and tissue damage. Through integrated molecular, cellular and organismal approaches, we aim to uncover unifying principles that govern immune recognition, viral countermeasures and tolerance breakdown, providing insights into the mechanisms that underlie infectious, inflammatory and autoimmune diseases.
Our research aims to understand how the innate immune system distinguishes self from non-self, how viruses evade host defences and how autoimmune responses contribute to disease progression
SCHOOL OF SCIENCE CAPABILITIES