Orthopedics This Week - 2018 | July 17, 2018 | Page 19

ORTHOPEDICS THIS WEEK
VOLUME 14, ISSUE 23 | JULY 17, 2018
is characterized by cellular infiltration
and inflammation. Moreover, success-
ful therapy decreases this synovial
inflammation.”
“In the past, our department showed
(PMID: 21177292; PMID: 24574210)
that in autoantibody positive at-risk
individuals there is no overt cellular
infiltration present in the synovium.”
“In the current study we performed a
so-called discovery-based approach
to investigate at a genome-wide gene
ex pression level (using microarrays)
whether the synovium is altered at a
molecular level before onset of RA.”
“Our molecular and microscopic
studies show differences between
those at-risk individuals who devel-
oped disease and those we did not.
Our research study shows that already
years before onset of clinical symp-
toms, the synovium is changing. This
is important information, since this
gives more insight into the pathogen-
esis of disease and may lead to the
identification of new drug targets for
preventive intervention”
“Now we can identify individuals at
risk of developing RA and with better
predictive biomarkers within reach,
preventive medicine for RA may be a
realistic development.”
19
Oxygen-Deprived Stem
Cells More Effective at
Making Bone
D
epriving stem cells of oxygen
and forming them into spheroids
before using them to treat bone defects
increases their ability to form new bone
“However, we first need to delineate
the best drug targets for this preclinical
phase of disease.”
“Investigating the target tissue of a
disease is highly important in order
to understand disease pathogen-
esis. A close collaboration between
orthopedic surgeons and rheumatol-
ogy researchers can be very helpful in
obtaining tissues (e.g. synovium, bone
and bone marrow) for research pur-
poses.” — EH
Wikimedia Commons and U.S. FDA
COMPLETE
CONVERTIBLE
INNOVATIVE
Anatomic
Reverse
MEDACTA.COM
SHOULDER-2_7.5x4.5_v00.indd 1
Advertisement
08.02.2018 16:33:40
ryortho.com | 1-888-352-1952