Orthopedics This Week - 2018 | July 17, 2018 | Page 18

ORTHOPEDICS THIS WEEK
VOLUME 14, ISSUE 23 | JULY 17, 2018
BIOLOGICS
Milestone Study
Accurately Predicts
Rheumatoid Arthritis
H
ow do we predict the presence
of rheumatoid arthritis in at-risk
patients and prevent it with early inter-
ventions?
These are the question researchers were
asking in their recent study “Gene Sig-
natures and Biomarkers Predict Onset
of Rheumatoid Arthritis in At-Risk
Individuals.” The study appears in the
June 2018 Annual European Congress of
Rheumatology.
According to the researchers, “Rheuma-
toid arthritis (RA) is characterized by
joint inflammation leading to destruc-
tion of bone and cartilage. Since struc-
18
tural joint damage is irreversible, early
recognition and treatment is a key focus
in an effort to halt the progression of the
disease.”
“There is a phase before any evidence
of RA where specific autoantibodies are
present in the body. Individuals who
have these antibodies are referred to as
RA-risk, however only a subset of these
will develop active disease in the short
term.”
Co-author, Dr. Lisa van Baarsen, prin-
cipal investigator at the Amsterdam
Rheumatology and Immunology Cen-
ter, told OTW, “The discovery that
autoantibodies can be present years
before the onset of clinical symptoms
of RA enables us to study autoantibody
positive individuals who are at risk of
developing RA.”
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“In patients with established disease the
target tissue of RA, the synovial joints,
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