NTU Undergraduates' research April 2014 - Biosciences | Page 128

Bisphenol A (BPA) is an endocrine disrupting chemical, which is widely in the manufacture of
plastics. This study investigated the effect of exposure to BPA on the neuronal differentiation and
development. The effect of BPA of the activity of acetylcholinesterase was also assessed as well as
the production or oxygen radical species. The mitochondrial permeability impairment in the
presence of BPA was also covered. The results confirmed that BPA impairs neuronal function though
a mechanism of dopamine efflux temporal patterning via membrane ERs. Oxidative Radical Species
produced in the assay was impaired with the addition of BPA. The NAC activity is degrading radically,
while the BPA effect is more apparent in the higher dose (500
M). In the TMRM assay
suggested that there was some evidence of difference in activity from the washed and unwashed
samples, although neither sample was treated with BPA.