Living life,
without
compromise
Effective pain relief and increased WOMAC function score1
• Equally effective as comparators* in treating arthritic
symptoms in OA, RA and AS2
Effective gastroprotection 3,4
• With a built-in PPI3
Least likely to increase CV risk5
• Lower risk of CV events with naproxen vs. other
traditional NSAIDS and COX-2 inhibitors 6
Sequential delivery 3
• Immediate-release esomeprazole followed by
EC naproxen3
• In a single convenient tablet3
OA – Osteoarthritis
PPI – Proton pump inhibitor
COX - Cyclo-oxygenase
RA – Rheumatoid ar thritis
CV – Cardiovascular
EC – Enteric coated
AS – Ankylosing spondylitis
NSAID – Non-Steroidal ?F???f???F?'?G'Vp??6??&F?'2??6?VFS??&??V???'W&?fV??F?6??fV?2???WF?&?fV??WF?&?6???"?f??VB?F?6RF?6??fV?26?F?V??W0??6?&?7F????VffV7F?fR??&V?Vbv?F?'V??B???v7G&?&?FV7F???0??&VfW&V?6W3?????6?&W&r?2?f?'B?r?7fV?76????WB??f??VB?F?6R6??&??F????bV?FW&?2?6?FVB?&??V??B???VF?FR?&V?V6RW6??W&???R?26??&&?RVff?67?F?6V?V6???"f?"??VR?7FV?'F?&?F?3?Gv?&?F???V@?G&??2?7W'"?VB&W2???#?#r?b??#C2?#S2?"?FGF?2??V???V?B"?6?FF?V???Vff?67??BF??W&&??G??b?&??V??W6??W&???R?v?W6?V?F&?WG26??&VBv?F?????7V6?f?2?4?G2?B4???"??&?F?'3??7?7FV?F?2&Wf?Wr?B?WGv?&???6W2?&?WV?&W2b&Wb#3?S????2?v?r?6?F???f?'B?????r??WB???&?6????WF?72?B&V?F?fR&??f??&??G??bf??VB?F?6R6??&??F????bV?FW&?2?6?FVB?&??V???B????V?FW&?2?6?FVBW6??W&???R?v?W6?V???6???&?6??##?S"?R??cs?c??B?v??G7FV???????6?&W&r?2?f?'B?r?WB??6???6?G&?âF?R??6?FV?6R?b?4?B?76?6?FVBV?F?66??2v7G&?2V?6W'2???F?V?G2G&VFVBv?F??C??&??V??W2W6??W&???R?v?W6?V?g2?V?FW&?2?6?FVB?&??V????R???V?B?&?6??F?W"#?3"?2??C?C2?R??4vWGF?v???V?'?B?6&F??f67V?"&?6?v?F?????7FW&??F???F???f???F?'?G'Vw3?7?7FV?F?2&Wf?Wr?b?V?F????&6VB6??G&???VB?'6W'fF????7GVF?W2???2?VF?6??R#?????????b?&?7F???????VF???V?B"?WB??6?F??6??6V?7W2wV?FV??W2?????r?FW&????7FW&??F??F???f???F?'?G'VrF?W&??BF?R?VVBf?"v7G&?&?FV7F????&V?Vf?G2fW'7W2&?6?2???V?B?&?6??F?W"#??#??C??C?b??3Bd???d? *?S?#?r?F&?WB??&Vr????CR?2??s??4???4?D????V6?F&?WB6??F??2S?r?&??V??B#?rW6??W&???R?2W6??W&???R?v?W6?V?G&???G&FR????$?4???t?4?4?54?d?4D????2??F?&?WV?F?72??F???f???F?'?vV?G2????D?4D???3?7??F??F?2&V?Vb??F?RG&VF?V?B?b&?WV?F??B'F?&?F?2??7FV?'F?&?F?2?B???6??p?7??G??F?2???F?V?G2?VVF??r&?F???V???&?F?'2F?&VGV6RF?R&?6??bFWfV????r????7FW&??F??F???f???F?'?G'Vw2??4?G2?76?6?FVBv7G&?2?B??"GV?FV??V?6W'2?d???d? *??2?&Vv?7FW&VBG&FV?&??bF?R7G&?V?V6w&?W?b6????W2?f?"gV??FWF??2&V?F??rF?????f?&?F????V?F???VB&?fR?V6R&VfW"F?F?R&?fVB6?vR??6W'B?7G&?V?V6?&?6WWF?6?0??G???FB?&Vr??????"?S?SB?r?'V??F??r"???'F?F?v?2?ff?6R&??rvV?&v??7&W66V?BvW7B?''??7F???#??&?fFR&r?#2?''??7F???##?FVâ??s?r?c?f????s?r?c??wwr?7G&?V?V6?6????W??'?FFS??V?R#R???r???d??b?2??