42
LMS Issue 3 | 2014
Special Chemistries
Solid-core Particle Technology
W
at e r s C or p or at ion of f e r s
CORTECS™ columns,
a family of 1.6µ solid-core Ultra
Performance LC® columns that set a
new standard in LC column performance. The higher efficiency brought
by these columns allows laboratories
to produce greater amounts of information faster.
Available in C18 , C18+ or HILIC
chemistries, Waters offers the columns
in 30 unique column configurations.
When used together with the lowdispersion Waters® Acquity UPLC®,
UPLC I-Class and UPLC H-Class
systems, CORTECS columns offer new
levels of UPLC performance.
CORTECS column particles feature
a solid, impermeable silica core encased
in a porous silica outer layer where the
A
interactions between the stationary
phase and the analytes occur.
The
CORTECS
chemistries
are used for:
• C18 column is a general-purpose,
Efficient Analysis with
the SMS DVS-HT
wide range of synthetic and natural
chemistry-based industries are
increasingly dependent upon efficient
analysis of raw materials, active ingredients and proprietary formulations to
remain competitive. In 1993, Surface
Measurement Systems introduced its
pioneering Dynamic Vapor Sorption
(DVS) technique for automated water
and organic vapor sorption studies. This
single sample configuration of the DVS-1
produced a 10- to 100-fold decrease
in analysis time and greatly improved
accuracy when compared with manual
methods.
W it h t h e n e w
DV S - H T H i g h
Throughput system,
product iv it y is
further increased
by another 10- to
20-fold via a novel robotic-based system
that incorporates a rotating carousel
performing tests in parallel mode.
The HT offers a range of state-of-theart features as standard equipment,
including multivapour compatibility to
accommodate a wide range of water and
organic vapour experiments, and built-in
video microscopy to capture visual images
of transitions and transformations in
real-time.
DVS-HT Application Areas:
• Stability studies to select optimal
drug and excipient combinations
• Rapid screens of salts, solvates,
hydrates, polymorphs and co-crystals
• Large scale pre-formulation and
formulation studies
• Characterisation of polymers, food
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