intrinsically and extrinsically , lamellar granules decline . This results in noticeable dryness . Rebuild or prevent a compromised lipid barrier by using phospholipids , ceramides , and plant extracts , like sunflower seed oil or olive leaf extract . These plants are valuable sources of linoleic acid ( essential fatty acid , Vitamin F ), needed for healthy barrier activity and tissue development .
Combining protease enzymes of the lipid barrier , such as the chymotryptic enzyme , with the hydrating chemicals of the NMF allows dead keratinocyte cells and old intercellular glue to desquamate ( cell turnover ). This action keeps our skin smooth , moisturized , and hydrated , and allows a new healthy barrier to emerge on a continual basis . Without a stable balance of each portion , proper barrier formation and function go awry , leading to various skin irritations , impaired cellular activity , premature aging , and potential disorders . In its entirety , this process is the crux of healthy skin .
Immunogenic Inflammation
When an external foreign antigen comes in contact with the skin , it can potentially alert the immune system . Langerhans Cells , dendritic macrophage-like skin cells throughout the epidermis , but predominantly in the stratum spinosum , will typically unite in the epidermis and ward off the offender ; but if the barrier is impaired this mechanism will not be as successful as usual . As immunogenic inflammation arises , cells can die or become damaged in the area of exposure , which the immune system views as a wound . Other cells in the area recognize this foreign threat . White blood cells of the immune system , such as macrophages and monocytes , respond , engulfing the threat and fighting off the substance . Impressive and protective , they release a series of chemicals that are toxic to the foreign invader , capable of destroying bacteria , unwanted debris , and viruses . This process can result in erythema , edema , and warmth in the skin . In most cases , inflammation experienced is acute and will fade and normalize rather quickly . On the rare occasion that inflammation is chronic , it can become a lingering cycle .
Neurogenic Inflammation
Less frequently discussed , neurogenic inflammation is a response of the nervous system . Our sensory nerves can be activated by chemical influences and other stressors ( UV , pro-inflammatory mediators ), which spark a cascade of the neuropeptides , calcitonin gene-related peptide ( CGRP ), Substance P ,
Many people with sensitive skin have other inflammatory issues affecting multiple areas of the body .