Sensitive Skin | by Deidre Ramdhanie
The three malfunctions are initiated by triggers , resulting in displayed characteristics .
Communication between three bodily systems : the integumentary system , the nervous system , and the immune system , induce the inflammatory pathway that can be visible or invisible and possibly cause a physical sensation .
Impaired Barrier Function
A genetically sensitive skin type naturally struggles to form and maintain a healthy , adequately functioning barrier . Post mitosis ( cell renewal ), the keratinocytes lack a sufficient amount of two barrier-dependent granules , keratohyalin
More of the world ’ s population claims to have sensitive skin than ever before . granules , and lamellar granules . Typically , their degranulation in the stratum granulosum , which is directly below the stratum corneum , creates the skin ’ s physical and chemical protective shield .
Keratohyalin granules perform two necessary tasks . The first is the protein release of profilligrin , which converts to filligrin , forming the cornified envelope on the cells ’ exterior . This is part of the barrier ’ s physical protection . The second is the release and containment of Natural Moisturizing Factor ( NMF ), which is actually what is being referenced when we repetitiously discuss “ skin hydration .” NMF is comprised of a series of water-soluble chemicals , such as urocanic acid , lactic acid , hyaluronic acid , PCA , glucosamine , potassium , magnesium , calcium , and urea . Therefore , humectants such as sodium PCA , hyaluronic acid and its derivatives , lactic acid , urea , glucose , and aloe readily absorb into the skin , joining the present NMF to boost skin hydration .
Degranulation of lamellar granules gives skin its required intercellular glue , made up of ceramides , essential fatty acids , and protease enzymes . This is a healthy water-soluble , lipid-rich secretion that weaves through the keratinocyte cells of the barrier , holding it intact and creating an acidic lipid barrier that repels foreign antigens and locks NMF in the skin , preventing transepidermal water loss ( TEWL ). A similarity between those with a genetically sensitive skin type and individuals with a genetically dry skin type is that both lack lamellar granules . As we age
88 iS Skin Source