flammation also contributes to the cells ’ declining ability to perform optimally .
There are many factors that define skin integrity and overall health . A few key variables include firmness , elasticity , moisture retention , sun protection ( melanin ), skin rejuvenation ( collagen protein synthesis ), sensitivity response , antioxidation , and pigmentation . All these factors are greatly affected by the skin ’ s exposure to the environment and other variables that are under epigenetic control . For example , environmental exposures such as pollution and chemicals , and lifestyle habits such as smoking , will cause epigenetic changes ( i . e ., DNA methylation ) resulting in gene inactivation . These inevitable modifications result in reduced synthesis ( creation ) of collagen and elastin , which contributes to wrinkling of skin . 1 Additionally , skin senescence or deterioration causes vascular network changes , decreasing the number of melanocytes and Langerhans cells , which decrease the thickness of the epidermis . 2
As each person ’ s skin health is influenced by his or her epigenetic status , the precise profiling of a person ’ s skin could potentially determine the selection of skincare products optimally
1 VK Kapoor and J Dureja , Aging : Approaches Towards its Control , Drug Discovery Today Therapeutic Strategies 7 ( 3 ) 43-44 ( 2010 )
2 TA Rando and HJ Chang , Aging , Rejuvenation , and Epigenetic Reprogramming : Resetting the Aging Clock , Cell 148 ( 1-2 ) 46-57 ( 2012 )
suited to each patient . For example , formulations of L-ascorbic acid ( vitamin C ) have been shown to decrease free radical damage and act as an antioxidant , neutralizing free radicals and thus curtailing premature aging of the skin . Other well-known antioxidants include vitamin A , vitamin E , and resveratrol . An individual may epigenetically respond more readily to one antioxidant preparation over another .
With the discovery and management of epigenetic data , actionable outcomes will result and will drive longevity and anti-aging research . On the forefront , the cosmetic industry has taken a serious interest in the promise of epigenetics and skin health . This has led to the discovery of ingredients and the development of products targeting epigenetic processes .
As we age , our body starts producing less collagen . The skin becomes thinner , drier , and less elastic . The loss of collagen leads to wrinkle formation and sagging skin .
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