2 ’ -FL ( HMO ) + ZINC L-CARNOSINE :
A NEW TREATMENT OPTION FOR GUT CONDITIONS
WHAT IS 2 ’ -FUCOSYLLACTOSE ( HMO )?
Human Milk Oligosaccharide ( HMO ) are the third most abundant component of human milk . 1 These structures are complex oligosaccharides made up of unconjugated glycans . While more than 150 different HMOs have been described to date , 2 ’ -Fucosyllactose ( 2 ’ -FL ) is the most abundant and therefore one of the most researched of the HMOs . 2
Most HMOs , including 2 ’ -FL ( HMO ), reach the large intestine undigested and intact where they impart physiological benefits on the host . These benefits have been well researched in infants and there is growing evidence substantiating the mechanism of actions in adults through pre-clinical and clinical studies : 1 , 3
Gastrointestinal Integrity
• 2 ’ -FL ( HMO ) exhibits anti-inflammatory activity in the large intestine and strengthens the gut wall . 1
• Provides support for tight junction formation in the intestinal barrier through the increases in short chain fatty acid ( SCFA ) production . 4 , 5
Microbial Balance
• Resistant to human enzymatic activity , 2 ’ -FL ( HMO ) acts as a prebiotic to normalise colonic function . 6
• Unlike other prebiotics , such as GOS or FOS , 2 ’ -FL ( HMO ) exclusively favours the growth of beneficial bacteria . 6
• Supplementation with 2 ’ -FL ( HMO ) in adults is associated with bifidogenic and butyrogenic effects increasing Short-Chain Fatty Acid ( SCFA ) production . 7
• Supports management of IBS and Ulcerative Colitis symptoms with minimal side effects . 8
Immune Function
• 2 ’ -FL ( HMO ) exhibits immunomodulatory and anti-inflammatory activity within the large intestine . 9 , 10
• 2 ’ -FL ( HMO ) inhibits epithelial adhesion of intestinal pathogens for the prevention of viral and bacterial infections . 1
• 2 ’ -FL ( HMO ) support immune balance by reducing pro-inflammatory cytokine secretion . 1
ZINC L-CARNOSINE ( FROM POLAPREZINC )
Gastrointestinal Integrity
• Zinc L-Carnosine ( from polaprezinc ) exhibits a protective role in wound healing . 11
• Evidence supports the safety and efficacy of Zinc L-Carnosine for the maintenance , prevention , and treatment of the mucosal lining and other epithelial tissues and its use for gastric ulcers and conditions of the upper gastrointestinal tract . 11
• Protects the intestinal lining against damage from medication-induced injuries . 11
• Studies also conclude Zinc L-Carnosines ’ ability in improving taste disorders . 12
Immune Function
• Zinc is an essential trace element crucial for the maintenance of both innate and adaptive immune functions .
• Involved in the modulation of the proinflammatory immune response , Zinc supports control of oxidative stress and helps to regulate inflammatory cytokines . 13
Microbial Balance |
2 ’ FL Immunity ZINC |
Gut Wall Repair |
A therapeutic combination that supports : Microbial balance Immunity |
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Gastrointestinal wall integrity |
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Gastrointestinal Wall Integrity |
Taste & Smell Sensation |
Gut wall repair Taste and smell sensations |
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FOR PROFESSIONAL REFERENCE ONLY |
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References : 1 . Rousseaux , A ., et al . 2021 . Front . Immunol . 12L680911 . DOI : 10.3389 / fimmu . 2021.680911 2 . Castanys-Munoz , E ., Martin , M . J . & Prieto , P . A . 2013 . Nutrition Reviews , 71 ( 12 ), 773-789 . DOI : 10.1111 / nure . 12079 3 . Eilson , E ., et al . 2016 . British Journal of Nutrition , 116 , 1356-1368 . DOI : 10.1017 / S0007114516003354 4 . Šuligoj , T ., et al . 2020 . Nutrients , 12 , 2808 . DOI : 10.3392 / nu12092808 5 . Peng , L ., et al . 2009 . The Journal of Nutrition , 139 , 1619-1625 . DOI : 10.3945 / jn . 109.104638 6 . Salli , K ., et al . 2021 . J . Agric . Food Chem , 69 , 170-182 . DOI : 10.1021 / acs . jafc . 0C06041 7 . Musilova S , et al . 2014 . Beneficial Microbes . 5 ( 3 ): 273-283 . doi : 10.3920 / bm2013.0080 8 . Ryan , J . J ., et al . 2021 . Nutrients , 13 , 938 . DOI : 10.3390 / nu13030938 9 . Quitadamo PA . et al . 2021 . Front Public Health . 8:589736 . DOI : 10.3389 / fpubh . 2020.589736 10 . Plaza-Díaz , J ., et al . 2018 . Nutrients . 10 ( 8 ), 1038 . https :// doi . org / 10.3390 / nu10081038 11 . Watari , I ., et al . 2013 . BMC Gastroenterol , 13 ( 108 ). DOI : 10.1186 / 1471-230X-13-108 12 . Hewlings , S ., & Kalman , D . 2020 . Nutrients , 12 ( 3 ), 665 . DOI : 10.3390 / nu12030665 13 . Prasad , A . S . 2008 . Mol Med , 14 ( 5-6 ), 353-357 . DOI : 10.2119 / 2008-00033 .