Grants
Department of Defense
Grant type : Congressionally Directed Medical Research Program , Peer Reviewed Medical Research Program , Investigator-Initiated Research Award
Title : “ Cardiomyocyte Autonomous Contractility Defects in Hypoplastic Left Heart Syndrome ( HLHS )”
In March 2023 , Stephanie Nakano , MD , was awarded the Department of Defense ’ s Investigator- Initiated Research Award in the amount of $ 2,391,041 over four years . This award supports research that has the potential to profoundly impact the development and implementation of medical devices , drugs and clinical guidance that will enhance the precision and efficacy of prevention , diagnosis and treatment across a wide range of disciplines , including cardiovascular health . The goal of her project is to use induced pluripotent stem cell cardiomyocytes derived from HLHS patients as a model to interrogate the myofilament phenotype in HLHS , including the effects of chronic hypoxia on contractility , and as a platform to identify HLHS-specific medical therapies . At the end of 2023 , Dr . Nakano generated induced pluripotent stem cells and matured cardiomyocytes from three different patients , two with HLHS and one pediatric patient without congenital heart disease .
26 Children ' s Hospital Colorado Heart Institute