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Topical Herpes Treatments The topical form of acyclovir (Zovirax) is available, however it offers little benefit in the treatment of genital herpes & is predominantly used for treating cold sores (Oral HSV1). Other Treatments If you’re anything like me then you may have fallen foul of one or two products which claim to cure herpes but don't actually work at all, plus they are expensive. I won't mention any brands here for fear of running into legal issues. What I will say is everything I tried turned out to be a complete waste of money, but I will leave you to draw your own conclusions.