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Human herpes virus 4 Human herpes virus 4 (HHV4) is also known as the Epstein-Barr virus. It is the major cause of infectious mononucleosis, or "mono" - the "kissing disease." It is a contagious infection and is transmitted through saliva. Coughing, sneezing, or sharing eating utensils with an infected person can pass the virus from one person to another. Human herpes virus 5 Human herpes virus 5 (HHV5) is the official name of cytomegalovirus (CMV). CMV is also a cause of mononucleosis. In people with healthy immune systems, the virus may not even cause any symptoms. It can be sexually transmitted, can cause problems to newborns, and can cause hepatitis. CMV can be transmitted through sexual contact, breast-feeding, blood transfusions, and organ transplants. CMV infection is one of the most difficult complications of AIDS. It may lead to diarrhoea, severe vision problems including blindness, infections of the stomach and intestines, and even death. For a virus that barely causes a problem in most people with healthy immune systems, it can be amazingly nasty in people with damaged immune systems, such as people with AIDS.