Forum for Nordic Dermato-Venereology Nr 3, 2018 | Page 21

Maria Lagerstedt – Lichen sclerosus and vulvar squamous cell cancer
SCC, ERRα expression was lost or substantially decreased in
all samples. This reduction of ERRα in cancer progression
may associate with the inflammation-induced nature of
vulvar SCC.
• Overexpression of Serpin A1 was associated with the
pathogenesis of LS and vSCC. Tumor-cell specific Serpin
A1 expression was detected in both LS-dependent and
HPV-dependent vulvar SCC, and the expression levels
increased in a malignant progression. However, Serpin
A1 immunohistochemistry or serum levels seem not to be
useful as prognostic markers in LS or vSCC.
Forum for Nord Derm Ven 2018, Vol. 23, No. 3
List of original publications
I.
Lagerstedt M, Karvinen K, Joki-Erkkilä M, Huotari-Orava R, Snell-
man E, Laasanen SL. Childhood lichen sclerosus- A challenge for
clinicians. Ped Dermatol 2013; 30: 444–450.
II. Lagerstedt M, Huotari-Orava R, Nyberg R, Mäenpää JU, Snellman
E, Laasanen SL. Reduction in ERR is associated with lichen scle-
rosus and vulvar squamous cell carcinoma. Gynecol Oncol 2015;
139: 535–540.
III. Lagerstedt M, Huotari-Orava R, Nyberg R, Nissinen L, Farshchian
M, Laasanen S-L, Snellman E, et al. Tumor-cell specific Serpin A1
expression in vulvar squamous cell carcinoma. Submitted.
D issertation
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