Chemwatch : 34-9547 Version No : 5.1.1.1
Page 11 of 15 Fido ' s Flea Bomb
Issue Date : 05 / 31 / 2016 Print Date : 06 / 27 / 2016
The juvenile hormone mimics generally exhibit excellent acute and repeat dose hazard profiles in animals . Although they disrupt the normal endocrine function of insects , they do not do so in animals . For methoprene : Acute toxicity : Methoprene is practically nontoxic when ingested or inhaled and slightly toxic by dermal absorption . The oral LD50 for methoprene in rats is greater than 34,600 mg / kg , and in dogs is greater than 5000 mg / kg . It is slightly toxic by skin exposure , with reported dermal LD50 values of greater than 2000 to 3000 mg / kg in rabbits . Methoprene is not an eye or skin irritant , and it is not a skin sensitiser . The inhalation LC50 for methoprene in rats is greater than 210 mg / L . No overt signs of poisoning have been reported in incidents involving accidental human exposure to methoprene . Chronic toxicity : No methoprene-related effects were observed in 2-year feeding trials with rats given doses of 250 mg / kg / day , nor in mice given 30 mg / kg / day . Liver changes were observed in mice fed 50 to 250 mg / kg / day of methoprene during an 18-month study . Increased liver weights occurred in rats fed 250 mg / kg / day for 90 days , but not during a 24-month feeding study in which rats were fed 125 mg / kg / day . Reproductive effects : Experimental data indicate that no reproductive hazards are associated with methoprene . No methoprene-related effects were observed in three-generation reproduction studies in rats receiving dietary doses of 125 mg / kg / day . Teratogenic effects : There have been no teratogenic effects in animals dosed with methoprene ; teratogenic effects were not seen in rats at doses of about 25 mg / kg / day , or in rabbits at doses of about 15 mg / kg / day . Methoprene does not appear to be teratogenic . Mutagenic effects : Methoprene does not appear to be mutagenic . No methoprene-related mutagenic effects were observed in rats following a single dose of 2000 mg / kg . Carcinogenic effects : No tumors were seen in an 18-month feeding study with mice , or in a 24-month oncogenicity study with rats . These data suggest that methoprene is not carcinogenic . Organ toxicity : The target organ primarily affected by methoprene after long-term exposure is the liver . Fate in humans and animals : In mammals , methoprene is rapidly and completely broken down and excreted , mostly in the urine and feces . Some evidence suggests that methoprene metabolites are incorporated into natural body components . Methoprene is excreted unchanged in cattle faeces in amounts that are sufficient to kill some larvae that breed in dung NOTE : Substance has been shown to be mutagenic in at least one assay , or belongs to a family of chemicals producing damage or change to cellular DNA . [ * The Pesticides Manual , Incorporating The Agrochemicals Handbook , 10th Edition , Editor Clive Tomlin , 1994 , British Crop Protection Council ] Toxicity Class WHO Table 5 ; EPA IV * ADI 0.1 mg / kg b . w . * Olfaction changes , somnolence , body temperature decrease , changes in adrenal weight recorded . NOEL : In 2-year feeding trials , rats 5000 mg / kg diet , mice 2500 mg / kg diet No teratogenic effects on rats at 1000 mg / kg , rabbits at 5000 mg / kg . No mutagenic effects on rats at 2000 mg / kg . No adverse reproductive effects in a 3-generation study on rats at 2500 mg / kg diet *
PROPANE No significant acute toxicological data identified in literature search .
Acute Toxicity
Skin Irritation / Corrosion
Serious Eye Damage / Irritation
Respiratory or Skin sensitisation
Mutagenicity
Carcinogenicity
Reproductivity
STOT - Single Exposure
STOT - Repeated Exposure
Aspiration Hazard
Legend : – Data available but does not fill the criteria for classification – Data required to make classification available – Data Not Available to make classification
SECTION 12 ECOLOGICAL INFORMATION
Toxicity
Ingredient
|
Endpoint |
Test Duration ( hr ) |
Species |
Value |
Source |
permethrin |
EC50 |
96 |
Algae or other aquatic plants |
0.005mg / L |
3 |
permethrin |
BCFD |
24 |
Algae or other aquatic plants |
1mg / L |
4 |
permethrin |
EC10 |
144 |
Crustacea |
0.000009mg / L |
4 |
permethrin |
EC50 |
48 |
Crustacea |
0.000112mg / L |
4 |
permethrin |
LC50 |
96 |
Fish |
0.00062mg / L |
4 |
permethrin |
NOEC |
96 |
Crustacea |
0.000025mg / L |
4 |
methoprene |
EC50 |
96 |
Algae or other aquatic plants |
0.023mg / L |
3 |
methoprene |
LC50 |
96 |
Fish |
0.778mg / L |
3 |
methoprene |
EC50 |
120 |
Crustacea |
0.055mg / L |
4 |
methoprene |
EC50 |
48 |
Crustacea |
0.071mg / L |
4 |
methoprene |
NOEC |
96 |
Crustacea |
0.001mg / L |
4 |
propane |
EC50 |
384 |
Crustacea |
2.462mg / L |
3 |