Chemwatch : 34-9547 Version No : 5.1.1.1
Page 10 of 15 Fido ' s Flea Bomb
Issue Date : 05 / 31 / 2016 Print Date : 06 / 27 / 2016
ChemicalWatch Fact Sheet Takahashi , O ., S . et al : Fundamental and Applied Toxicology : Vol 22 ., pp 293-303 , Feb 1994
Fido ' s Flea Bomb
TOXICITY Not Available
IRRITATION Not Available permethrin
TOXICITY dermal ( rat ) LD50 : 1750 mg / kg [ 2 ] Oral ( rat ) LD50 : 383 mg / kg [ 2 ]
IRRITATION Skin ( rabbit ): 500 mg / 24h - mild
TOXICITY IRRITATION methoprene
Dermal ( rabbit ) LD50 : > 2000 mg / kg [ 2 ] Eye ( rabbit ): non-irritating * Inhalation ( rat ) LC50 : > 210 mg / L / 4hr [ 2 ] Skin ( rabbit ): non-irritating * Oral ( rat ) LD50 : 25000 mg / kg [ 2 ]
TOXICITY Inhalation ( mouse ) LC50 : > 15.6- < 17.9 mm / l / 2hr [ 1 ]
IRRITATION
Not Available
Inhalation ( mouse ) LC50 : 410000 ppm / 2hr [ 1 ] Inhalation ( rat ) LC50 : > 800000 ppm15 min [ 1 ] propane
Inhalation ( rat ) LC50 : 1354.944 mg / L15 min [ 1 ] Inhalation ( rat ) LC50 : 1355 mg / l15 min [ 1 ] Inhalation ( rat ) LC50 : 1442.738 mg / L15 min [ 1 ] Inhalation ( rat ) LC50 : 1443 mg / l15 min [ 1 ] Inhalation ( rat ) LC50 : 570000 ppm15 min [ 1 ] butane
TOXICITY Inhalation ( rat ) LC50 : 658 mg / L / 4hr [ 2 ]
IRRITATION Nil reported
Legend : 1 . Value obtained from Europe ECHA Registered Substances - Acute toxicity 2 .* Value obtained from manufacturer ' s SDS . Unless otherwise specified data extracted from RTECS - Register of Toxic Effect of chemical Substances
PERMETHRIN
The following information refers to contact allergens as a group and may not be specific to this product . Contact allergies quickly manifest themselves as contact eczema , more rarely as urticaria or Quincke ' s oedema . The pathogenesis of contact eczema involves a cell-mediated ( T lymphocytes ) immune reaction of the delayed type . Other allergic skin reactions , e . g . contact urticaria , involve antibody-mediated immune reactions . The significance of the contact allergen is not simply determined by its sensitisation potential : the distribution of the substance and the opportunities for contact with it are equally important . A weakly sensitising substance which is widely distributed can be a more important allergen than one with stronger sensitising potential with which few individuals come into contact . From a clinical point of view , substances are noteworthy if they produce an allergic test reaction in more than 1 % of the persons tested . The material may cause skin irritation after prolonged or repeated exposure and may produce a contact dermatitis ( nonallergic ). This form of dermatitis is often characterised by skin redness ( erythema ) and swelling epidermis . Histologically there may be intercellular oedema of the spongy layer ( spongiosis ) and intracellular oedema of the epidermis . The substance is classified by IARC as Group 3 : NOT classifiable as to its carcinogenicity to humans . Evidence of carcinogenicity may be inadequate or limited in animal testing . [ * The Pesticides Manual , Incorporating The Agrochemicals Handbook , 10th Edition , Editor Clive Tomlin , 1994 , British Crop Protection Council ] Oral ( rat ) LD50 : 430-4000 mg / kg * Oral ( mouse ) LD50 : 540-2960 mg / kg * cis / trans ratio : 40:60 cis / trans ratio : 20:80 ADI : 0.05 mg / kg for nominal cis-trans 40:60 and 25:75 isomers only
METHOPRENE
Asthma-like symptoms may continue for months or even years after exposure to the material ceases . This may be due to a non-allergenic condition known as reactive airways dysfunction syndrome ( RADS ) which can occur following exposure to high levels of highly irritating compound . Key criteria for the diagnosis of RADS include the absence of preceding respiratory disease , in a non-atopic individual , with abrupt onset of persistent asthma-like symptoms within minutes to hours of a documented exposure to the irritant . A reversible airflow pattern , on spirometry , with the presence of moderate to severe bronchial hyperreactivity on methacholine challenge testing and the lack of minimal lymphocytic inflammation , without eosinophilia , have also been included in the criteria for diagnosis of RADS . RADS ( or asthma ) following an irritating inhalation is an infrequent disorder with rates related to the concentration of and duration of exposure to the irritating substance . Industrial bronchitis , on the other hand , is a disorder that occurs as result of exposure due to high concentrations of irritating substance ( often particulate in nature ) and is completely reversible after exposure ceases . The disorder is characterised by dyspnea , cough and mucus production .