CardioSource WorldNews Interventions September / October 2013 | Page 2

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December 6-7, 2013  

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January 11-15, 2014

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The New York Hilton
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Snowmass, Colorado

How to Become a
Cardiovascular Investigator

46th Annual New York
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45th Annual Cardiovascular
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January 16-18, 2014

Cardiovascular Summit:
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ADVERTISEMENT

Low levels of
platelet inhibition
can raise some
*
questions
1-6

Factors that may impact platelet inhibition*
for patients taking an oral antiplatelet include:
• Genetic variation7-9
• Concomitant medications10-12
• Preexisting conditions that may impact antiplatelet response
(eg, diabetes, obesity)13-15
• Patient noncompliance16-18
• Side effects that impact adherence19
*The relationship between inhibition of platelet aggregation and clinical activity
has not been established.

Have you considered these factors when selecting an oral antiplatelet?

References: 1. Buonamici P, Marcucci R, Migliorini A, et al. J Am Coll Cardiol. 2007;49:2312-2317. 2. Matetzky S, Shenkman B, Guetta V, et al. Circulation.
2004;109:3171-3175. 3. Cuisset T, Frere C, Quilici J, et al. J Thromb Haemost. 2006;4:542-549. 4. Hochholzer W, Trenk D, Bestehorn H-P, et al. J Am Coll Cardiol.
2006;48:1742-1750. 5. Marcucci R, Gori AM, Paniccia R, et al. Circulation. 2009;119:237-242. 6. Bonello L, Tantry US, Marcucci R, et al; for the Working Group
on High On-Treatment Platelet Reactivity. J Am Coll Cardiol. 2010;56:919-933. 7. Brandt JT, Close SL, Iturria SJ, et al. J Thromb Haemost. 2007;5:2429-2436.
8. Varenhorst C, James S, Erlinge D, et al. Eur Heart J. 2009;30:1744-1752. 9. Frere C, Cuisset T, Morange P-E, et al. Am J Cardiol. 2008;101:1088-1093. 10. Gilard M,
Arnaud B, Cornily J-C, et al. J Am Coll Cardiol. 2008;51:256-260. 11. Farid NA, Payne CD, Small DS, et al. Clin Pharmacol Ther. 2007;81:735-741. 12. Yun KH, Rhee SJ,
Park H-Y, et al. Int Heart J. 2010;51:13-16. 13. Angiolillo DJ, Fernandez-Ortiz A, Bernando E, et al. Diabetes. 2005;54:2430-2435. 14. Angiolillo DJ, Bernardo E,
Ramírez C, et al. J Am Coll Cardiol. 2006;48:298-304. 15. Angiolillo DJ, Fernández-Ortiz A, Bernardo E, et al. J Invasive Cardiol. 2004;16:169-174. 16. Baran KW,
Lasala JM, Cox DA, et al; for ARRIVE Investigators. Am J Cardiol. 2008;102:541-545. 17. Ergelen M, Uyarel H, Osmonov D, et al. Clin Appl Thromb Hemost.
2010;16:33-41. 18. Iakovou I, Schmidt T, Bonizzoni E, et al. JAMA. 2005;293:2126-2130. 19. Ho PM, Bryson CL, Rumsfeld JS. Circulation. 2009;119:3028-3035.
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