ATMS Journal Winter 2025 (Public Version) | Page 33

medicine and electro-acupuncture in two patients with breast cancer and severe liver disease who could not receive standard anaesthesia therapy due to liver pathology. The team used homeopathic treatment( Arnica montana 15C and Apis mellifica 15C) before and after surgery and an electro-acupuncture treatment performed in the pre- and post-surgical phases without any analgesic / pain relieving medications. Both patients treated with the integrated approach improved their overall condition without the need for other common pain-relieving medicines.

5. Macias-Cortes EDC, et al. Response to Individualized Homeopathic Treatment for Depression in Climacteric Women with History of Domestic Violence, Marital Dissatisfaction or Sexual Abuse: Results from the HOMDEP-MENOP Study. Homeopathy. 2018:107( 3): 202- 208. The aim of this study was to assess the association between individualised homeopathic treatment or fluoxetine and a response to depression treatment in climacteric women experiencing high levels of domestic violence, sexual abuse or marital dissatisfaction, using a randomised, placebo-controlled, doubleblind, double-dummy, three-arm trial design, with a 6-week follow-up. A total of 133 women with moderate-to-severe depression were enrolled in the trial.

Domestic violence, marital dissatisfaction and sexual abuse were assessed at baseline. Response to depression treatment was defined by a decrease of 50 % or more from baseline score using the Hamilton scale. The possible association between domestic violence, sexual abuse, and marital dissatisfaction and response to depression treatment was analysed with bivariate analysis in the three groups. An analysis of the results showed that treatment with homeopathy was associated with a statistically significant improvement in depression, after adjusting for sexual abuse, domestic violence and marital dissatisfaction.

6. Oberai P, et al, Effectiveness of Homeopathic Medicines as Add-on to Institutional Management Protocol for Acute Encephalitis Syndrome in Children: An Open-Label Randomized Placebo-Controlled Trial. Homeopathy. 2018:107( 3): 161- 171. This Indian study was designed to assess the effects of homeopathic treatment as an addition to a standard institutional management protocol( IMP) for children diagnosed with acute encephalitis syndrome, using a randomised placebo-controlled trial design at an Indian paediatric unit where data was collected from 2013 to 2015. Children aged > 6 months and ≤ 18 years and receiving IMP were randomised to receive adjunctive homeopathy( H) or placebo as control( C). The primary effectiveness analysis was based on Glasgow Outcome Scale( GOS). Morbidity was assessed using the Liverpool Outcome Score for Assessing Children at Follow-up. Analysis was by intention to treat. Data from a total of 612 children was analysed( H = 304; C = 308). The primary outcome, GOS, differed significantly between H and C groups. There was 14.8 % death / neuro-vegetative state in the H group compared to 29.8 % in the C group. Relative risk was 0.49( 95 % confidence interval [ CI ]: 0.36 to 0.68), with absolute risk reduction of 15.0 %( 95 % CI: 8.6 to 21.6 %). The most frequently used medicines were Belladonna( n = 116), Stramonium( n = 33), Arsenicum album( n = 25), Sulfur( n = 18), Opium( n = 17), and Nux vomica( n = 10).

In-Vitro Research

1. Sekers S, et al. Evidence that Extreme Dilutions of Paclitaxel and Docetaxel Alter Gene Expression of In-vitro Breast Cancer Cells. Homeopathy. 2018:107( 11): 32-39. This work investigated the effects of homeopathic preparations of the taxane anti-cancer drugs, which are not commonly used in homeopathic medicines, on mRNA expression profiles of five key genes( p53, p21, COX-2, TUBB2A and TUBB3) in the breast cancer cell line, MCF-7. To do this, MCF-

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