( 16.7 %), psychological ( 13.9 %) and genitourinary complaints ( 12.3 %), with 66.7 % suffering from these problems for at least 1 year . The three symptoms that bothered patients the most were pain , mental symptoms and tiredness / fatigue . A paired-samples t-test using an intention-to-treat analysis showed that the MYMOP2 profile score improved from 4.25 ( IQR 3.50-5.00 ), with a mean change of 1.24 ( 95 % CI 1.04 , 1.44 ) from the first to the last consultation ( p < 0.001 ). Results were statistically significant both for completers ( n = 91 ) ( p < 0.001 ) and non-completers ( n = 107 ) ( p < 0.001 ) using last-observation-carried-forward , although completers did better than noncompleters ( p < 0.001 ). The overall clinical significance of improvements was at least moderate . A repeated measures ANOVA test also showed statistically significant improvements ( p < 0.001 ).
4 . Oberai P , et al . A multicentric randomized clinical trial of homoeopathic medicines in fifty millesimal potencies vis‐a‐vis centesimal potencies on symptomatic uterine fibroids . Indian J Res Homoeopathy . 2016 ; 10:24-35 . This multi-centre randomised clinical trial was conducted at six centres by India ' s Central Council for Research in Homoeopathy with the primary aim to evaluate the effects of homeopathic medicines in fifty millesimal ( FM ) potencies compared to centesimal ( C ) potencies on symptomatic uterine fibroids . All assessments were carried out by a specialist obstetrician / gynaecologist and the specialist homeopathic physicians engaged were responsible for the homeopathic prescriptions and follow up , which occurred over 12 months . The primary outcome measures were changes in the symptoms of uterine fibroids on a visual analogue scale ( VAS ) of 0 – 10 and findings through ultrasonography ( USG ) between FM and C potencies . The secondary outcome was changes in uterine fibroid symptom quality of life questionnaire ( UFSQOL ). Data analysis was done as per intention to treat ( ITT ) analysis . A total of 209 subjects were enrolled in the study , ( FM : 106 and C : 103 ), and their data analysed under a modified ITT . FM and C potencies were equally effective in reducing the symptoms ( percentage change ) due to uterine fibroid on VAS scale after 1 year of treatment ( P > 0.05 ). The health-related quality of life ( HRQOL ) and sub-domains of UFSQOL also showed equal effectiveness in both the groups ( P = 0.05 ). However , no difference was observed in all the USG findings except for uterine volume ( P = 0.03 ). There was a statistically significant difference before and after homeopathic treatment irrespective of assigned groups ( i . e ., FM or C ( P < 0.05 )) in all of the above parameters . The medicines most frequently prescribed were Pulsatilla , Sulphur , Lycopodium , Sepia , Phosphorus , Calcarea carbonica , and Natrum muriaticum .
5 . Das KD , et al . Treatment of hemorrhoids with individualized homeopathy : An open observational pilot study . J Intercult Ethnopharmacol . 2016 ; 5 ( 4 ): 335-42 . In this prospective , open , observational trial , haemorrhoid patients were treated using five standardised scales that measured complaint severity and anoscopic score . It was conducted at two homeopathic hospitals in India , from mid-July 2014 to mid-July 2015 . Patients were treated with individualised homeopathy and followed up every month up to 6 months . A total of 73 patients were screened ; 52 enrolled , 38 completed , and 14 dropped out . Intention to treat population ( n = 52 ) was analysed in the end . Statistically significant reductions of mean bleeding ( month 3 : -21.8 , 95 % confidence interval [ CI ]: -30.3 , -13.3 , P : < 0.00001 , d = 0.787 ; month 6 : -25.5 , 95 % CI -35.4 , -15.6 , P : < 0.00001 , d = 0.775 ), pain ( month 3 : -21.3 , 95 % CI -28.6 , -14.0 , P : < 0.00001 , d = 0.851 ; month 6 : -27.6 , 95 % CI -35.6 , -19.6 , P : < 0.00001 , d = 1.003 ), heaviness visual analogue scales ( VASs ) ( month 3 : -8.1 , 95 % CI -13.9 , -2.3 , P : = 0.008 , d = 0.609 ; month 6 : -12.1 , 95 % CI -19.1 , -5.1 , P : = 0.001 , d = 0.693 ), and anoscopic score ( month 3 : -0.4 , 95 % CI -0.6 , -0.2 , P : < 0.0001 , d = 0.760 ; month 6 : -0.5 , 95 % CI -0.7 , -0.3 , P : < 0.0001 , d = 0.703 ) were achieved . Itching VASs reduced significantly only after 6 months ( -8.1 , 95 % CI -14.6 , -1.6 , P : = 0.017 , d = 0.586 ). The outcomes confirmed that individualised homeopathic treatment was effective in the management of haemorrhoids . The most frequently used medicines here were Sulphur , Nux vomica , Calc phos and Nat mur .
6 . Janardanan KR , et al . Homoeopathic Genus Epidemicus ‘ Bryonia alba ’ as a prophylactic during an outbreak of chikungunya in India : A cluster -randomised , double -blind , placebo controlled trial . Indian J Res in Homoeopathy . 2014 ; 8 ( 3 ): 160-5 . The objective here was to assess the usefulness of homeopathic Bryonia alba 30C in the prevention of chikungunya during its normal epidemic outbreak in the state of Kerala , India . A cluster-randomised , double-blind , placebo-controlled trial was conducted in two districts . Bryonia alba 30C or placebo were randomly administered to 167 clusters ( Bryonia alba 30C = 84 clusters ; placebo = 83 clusters ) out of which data on 158 clusters was analysed ( Bryonia alba 30C = 82 clusters ; placebo = 76 clusters ). Healthy participants ( absence of fever and arthralgia ) were eligible for the study ( Bryonia alba 30C n = 19750 ; placebo n = 18479 ). Weekly follow-up was done for 35 days . The infection rate in the study groups was analysed and compared by use of cluster analysis . The findings showed that 2,525 out of 19,750 people from the Bryonia alba 30 C group suffered from chikungunya , compared to 2,919 out of 18,479 in the placebo group . Cluster analysis showed a significant difference between the two groups [ rate ratio = 0.76 ( 95 % CI 0.14 - 5.57 ), P value = 0.03 ]. The result reflects a 19.76 % relative risk reduction by Bryonia alba 30C as compared to placebo .
7 . Barvalia PM , et al . Effectiveness of homoeopathic therapeutics in the management of childhood autism disorder . Indian J Res Homoeopathy . 2014 ; 8 ( 3 ): 147-59 . A team from Mumbai conducted this research with the objective of demonstrating the usefulness of the
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