ATMS Journal Summer 2024 (Public) | Page 24

natural spring waters in the range 30 to 130mg elemental magnesium per litre , and is in the form of MgCl2 . Therefore , regular drinking of magnesium mineral water provides optimal dietary intake without necessitating stomach digestion . Magnesium in drinking water also increases hydration capacity of the water , which supports mitochondrial metabolism and excretion of cell wastes .
However , high end magnesium needs can be catered for with additional daily transdermal magnesium supplementation , because magnesium chloride topical cream , lotion and spray , as well as magnesium bathing , have the potential of delivering much higher amounts of magnesium via epidermal absorption . Magnesium bathing can also enhance detox via skin .
The skin can store extra magnesium , particularly in the presence of lipids , which are skin-protective . There is no risk of overdose using this method , as the body is self-regulating via skin absorption of magnesium . Not only is the use of transdermal magnesium soothing and relaxing , helping to relieve stress , but regular daily use helps to restore cellular stores of magnesium over time .
More research is now being conducted to investigate the use of MgCl2 as an adjunct cancer treatment . “ Santos et al . found that MgCl2 causes apoptosis and significantly slows migration in cancer cells with varying metastatic potentials . MgCl2 inhibits invasion and metastasis by lowering V-H plus ATPase with myosin II expression , suppressing vimentin expression , and increasing E-cadherin expression , implying function for MgCl2 in EMT reversing . In addition , MgCl2 inhibits NF-k expression while promoting chromatin condensation .” 3
It should be noted that subclinical magnesium insufficiency can exist in tissue cells , but not necessarily be revealed by blood tests , as blood only contains about one per cent of the body ’ s magnesium , which is kept within a narrow range to support cardiovascular health . Tissue cells often sacrifice their stored magnesium in order to maintain magnesium balance in the blood . “ Metabolic unit depletion / repletion experiments show that serum magnesium concentrations decrease only after a prolonged depletion .” 8
As people get older , their immune systems lose their natural ability to fight infections , increasing their risk of infection , neoplasms , and autoimmune diseases , as well as their ability to heal skin wounds . Metabolic disorders , inflammation , respiratory illnesses , endothelial dysfunction , thrombosis , heart rhythm abnormalities , osteoporosis , depression and mental illnesses are all fundamentally magnesium-deficiency symptoms .
“ Illness load is linked to deterioration of immune system competence rather than chronological age .” 3 The common denominator in degenerative diseases and ageing is magnesium deficiency , which is why magnesium has been commonly referred to by researchers as ‘ the antiageing mineral ’.
REFERENCES
1 Pickering G , Mazur A , Trousselard M , Bienkowski P , Yaltsewa N , Amessou M , Noah L , Pouteau E . Magnesium status and stress : The vicious circle concept revisited . Nutrients 2020 , 12 ( 12 ), 3672 . https :// doi . org / 10.3390 / nu12123672 .
2 Maier JA , Castiglioni S , Locatelli L , Zocchi M , Mazur A . Magnesium and inflammation : Advances and perspectives . Seminars in Cell & Developmental Biology 2021 , 115 , 37 – 44 . https :// doi . org / 10.1016 / j . semcdb . 2020.11.002 .
3 Ashique S , Kumar S , Hussain A , Mishra N , Garg A , Gowda BHJ , Farid A , Gupta G , Dua
K , Taghizadeh-Hesary F . A narrative review on the role of magnesium in immune regulation , inflammation , infectious diseases , and cancer . Journal of Health , Population , and Nutrition 2023 , 42 , 74 . https :// doi . org / 10.1186 / s41043-023-00423- 0 .
4 Fujita K , Shindo Y , Katsuta Y , Goto M , Hotta K , Oka K . Intracellular Mg2 + protects mitochondria from oxidative stress in human keratinocytes . Commun Biol 2023 , 6 ( 1 ), 1 – 9 . https :// doi . org / 10.1038 / s42003- 023-05247-6 .
5 Cheung MM , Dall RD , Shewokis PA , Altasan A , Volpe SL , Amori R , Singh H , Sukumar D . The effect of combined magnesium and Vitamin D supplementation on Vitamin D status , systemic inflammation , and blood pressure : A randomized doubleblinded controlled trial . Nutrition 2022 , 99 – 100 , 111674 . https :// doi . org / 10.1016 / j . nut . 2022.111674 .
6 Lötscher J , Líndez A-A M , Kirchhammer N , Cribioli E , Attianese GM , Trefny MP , Lenz M , Rothschild SI , Strati P , Künzli M , Lotter C , Schenk SH , Dehio P , Löliger J , Litzler L , Schreiner D , Koch V , Page N , Lee D , Grählert J , Kuzmin D , Burgener A-V , Merkler D , Pless M , Balmer ML , Reith W , Huwley J , Irving M , King CG , Zippelius A , Hess C . Magnesium sensing via LFA-1 regulates CD8 + T-cell effector function . Cell 2022 , 185 ( 4 ), 585-602 . e29 . https :// doi . org / 10.1016 / j . cell . 2021.12.039 .
7 Karagülle O , Kleczka T , Vidal C , Candir F , Gundermann G , Külpmann WR , Gehrke A , Gutenbrunner C . Magnesium absorption from mineral waters of different magnesium content in healthy subjects . Forsch Komplementmed 2006 , 13 ( 1 ), 9 – 14 . https :// doi . org / 10.1159 / 000090016 .
8 Nielsen FH . Magnesium deficiency and increased inflammation : Current perspectives . J Inflamm Res 2018 , 11 , 25 – 34 . https :// doi . org / 10.2147 / JIR . S136742 .
216 | vol30 | no4 | JATMS