vitamin D and low magnesium ratio can promote hypercalcemia , which reduces magnesium ’ s potency .
As it ’ s easier to get enough calcium than enough magnesium from diet , and magnesium is excessively excreted under stressful conditions , there is a propensity for calcium to become dominant and deposit into soft tissue such as endothelial linings of blood vessels . This can be particularly exaggerated in a high carbohydrate diet due to anaerobic metabolism and corresponding insulin resistance .
In treating vitamin D deficiency , its supplementation should go hand in hand with magnesium supplementation , as well as avoidance of calcium supplementation ( except in rare circumstances of genuine calcium deficiency ). It is often the case that lifting magnesium status can eliminate symptoms of calcium deficiency where the problem isn ’ t a shortage of calcium , but rather how it is being regulated and used in the body .
Magnesium sufficiency is cancer-preventative
Magnesium also plays a critical role in preserving the active structure of macromolecules such as DNA , RNA , and ATP , damage to which is linked to cancer . Magnesium is involved in regulating second messengers derived from lipids and phosphoinositides , compensating for charge imbalances .
Oxidative stress and magnesium deficiency activate inflammatory pathways , which can lead to transformation of normal cells to tumour cells , their proliferation , chemoresistance , radio-resistance , invasion , angiogenesis , and stem cell survival , as T- and B-cell immune regulation becomes compromised and normal apoptosis of corrupted cells is suppressed . 6
“ A recent meta-analysis showed that a linear relationship exists between higher dietary magnesium intake and reduced cancer mortality , with a 5 % decrease in cancer mortality observed for every 100 mg / d increase in magnesium intake . Interestingly , lower dietary Mg intake may be associated with increased production of N-nitroso compounds , which are carcinogens .” 3
In studies on mouse models of cancer , researchers have demonstrated strengthening of the immune response of T-cells against tumour cells by an increase in local magnesium concentrations in the tumours . 6
Magnesium supplementation
Subclinical magnesium deficiency is common , especially in the ageing population , because of insufficient magnesium intake , excessive and chronic stress , medications , chronic diseases , and digestion and absorption issues . A magnesium-rich diet is recommended , but caution should be exercised with foods high in oxalates and other phytochemicals which block magnesium . Sufficient soaking and cooking techniques can help to release the bound magnesium – but make sure the cooking water is not discarded ! Soups , such as those recommended in the Gut and Psychology Syndrome ( GAPS ) protocol , are easier to digest and can support a magnesium-rich diet .
The consumption of drinking water with magnesium chloride ( MgCl2 ) can also serve as a significant means of obtaining magnesium via diet . 3 Dissolved magnesium chloride is already in the right form for solubility and cell absorption without further digestion . High concentrations of magnesium in any form attract water and have a laxative effect , which means most of the magnesium doesn ’ t make it across the gut wall to the interior . 7
The optimal magnesium uptake via gut wall is in concentrations found in
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