RECENT RESEARCH
Acupuncture and TCM
YE M , Zhang L , Yuan A . -H , Xie H-Y , Xi Y , Yang J . Rules of acupoint selection in treatment of cancer-related insomnia with acupuncture and moxibustion based on data mining technology . Zhen ci yan jiu ( Acupuncture research ). 2024 ; 49 ( 7 ): 726 – 735 . Doi : 10.13702 / j . 1000- 0607.20240085 .
Objectives : To analyze the rules of acupoint selection in treatment of cancer-related insomnia with acupuncture and moxibustion by data mining technology .
Methods : The articles of cancer-related insomnia treated with acupuncture and moxibustion were searched from CNKI , Wanfang , VIP , SinoMed , PubMed , WOS , Cochrane , and Embase databases , from the inception of each database to January 5 , 2024 . The prescription database of acupuncture and moxibustion for cancer-related insomnia was established . The descriptive analysis was conducted on the use frequency , meridian tropism and distribution of acupoints . Using SPSS Modeler 18.0 Apriori algorithm , the association rules of acupoint prescriptions were analyzed . With Cytoscape3.9.1 software used , the complex network diagram was plotted , and the cluster analysis of highfrequency acupoints was performed by SPSS26.0 software .
Results : Forty-one articles were included , and 67 prescriptions were extracted with 89 acupoints involved , and the total use frequency was 447 times . The top 4 acupoints of the high use frequency were Baihui ( GV20 ), Sanyinjiao ( SP6 ), Shenmen ( HT7 ) and Shenting ( GV24 ). The included meridians were the governor vessel , the spleen meridian , the bladder meridian , the conception vessel , the heart meridian and the stomach meridian . The selected acupoints were mostly distributed on the head , the neck and and the upper and lower limbs . The special acupoints of the high use frequency included the five- Shu points , the crossing points and yuan -primordial points . Regarding acupoint combination , GV24 , SP6 , HT7 , and GV20 were highly correlated . The three effective clusters were categorized among the top 12 acupoints of the high use frequency .
Conclusions : In treatment of cancerrelated insomnia with acupuncture and moxibustion , the principle focuses on supporting the healthy qi , eliminating pathogens , regulating yin and yang , promoting the circulation of the governor vessel for regulating the spirit , and tranquilizing the mind . The core acupoint prescription may includes GV24 , SP6 , HT7 and GV20 ; combined with Zusanli ( ST36 ) and Yintang ( GV4 + ) to enhance the therapeutic effect .
Klocke C , Rhein K , Cramer H , Kröger B , Wetzel AJ , Vagedes J , Mauch H , Beißner F , Joos S , Valentini J . A randomized controlled trial of acupuncture and receptive music therapy for sleep disorders in the elderly-ELAMUS : study protocol . BMC complementary medicine and therapies . 2024 ; 24 ( 1 ): 295 . Doi : 10.1186 / s12906- 024-04581-4 .
Background : Globally , the demographic shift towards an aging population leads to significant challenges in healthcare systems , specifically due to an increasing incidence of multimorbidity resulting in polypharmacy among the elderly . Simultaneously , sleep disorders are a common complaint for elderly people . A treatment with pharmacological therapies often leads to side effects causing a high potential for dependency . Within this context , there is a high need to explore non-pharmacological therapeutic approaches . The purpose of this study is to evaluate the effectiveness of acupuncture and music therapy , both individually and combined as a multimodal therapy , in the treatment of sleep disorders in individuals aged 70 years and older .
Methods : We conduct a confirmatory randomized controlled trial using a two-factorial study design . A total of n = 100 elderly people receive evidencebased standard care information for age-related sleep disorders . Beyond that , patients are randomly assigned into four groups of n = 25 each to receive acupuncture , receptive music therapy with a monochord , multimodal therapy with both acupuncture and music therapy , or no further therapy . The study ' s primary outcome measurement is the improvement in sleep quality as assessed by the Pittsburgh Sleep Quality Index ( PSQI ) ( global score ), at the end of intervention . Additionally , depression scores ( Geriatric Depression Scale ), health-related quality of life ( Short-Form-Health Survey-12 ), neurovegetative activity measured via heart rate variability , and safety data are collected as secondary outcomes . Using a mixed-methods approach , a qualitative process evaluation will be conducted to complement the quantitative data .
Discussion : The study is ongoing and the last patient in is expected to be enrolled in April 2024 . The results can provide valuable insights into the effectiveness of non-pharmacological interventions for sleep disorders among the elderly , contributing to a more personalized and holistic approach in geriatric healthcare .
Trial Registration : German Clinical Trials Register ( DRKS00031886 )
LI H , Ye XF , Su YS , He W , Zhang JB , Zhang Q , Zhan LB , Jing XH . Mechanism of acupuncture and moxibustion on promoting mucosal healing in ulcerative colitis . Chinese Journal of Integrative Medicine . 2024 ; 29 ( 9 ): 847 – 856 , 2023 . Doi : 10.1007 / s11655-022-3531-x .
The latest guideline about ulcerative colitis ( UC ) clinical practice stresses that mucosal healing , rather than antiinflammation , is the main target in UC clinical management . Current mucosal dysfunction mainly closely relates to the endoscopic intestinal wall ( mechanical barrier ) injury with the imbalance between intestinal epithelial cells ( IECs ) regeneration and death , as well as tight junction ( TJ ) dysfunction . It is suggested that biological barrier ( gut microbiota ), chemical barrier ( mucus protein layer , MUC ) and immune barrier ( immune cells ) all take part in the imbalance , leading to mechanical barrier injury . Lots of experimental
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