RECENT RESEARCH insufficiency , cognitive performance , mood disorders , loss of smell , taste , and hair , sweatiness , cough , pain in joints , muscles , and chest ) in the 30 days before randomization were included in the study of the efficacy of Chisan ®/ ADAPT-232 ( a fixed combination of adaptogens Rhodiola , Eleutherococcus , and Schisandra ) supplementation for two weeks . Chisan ® decreased the duration of fatigue and pain for one and two days , respectively , in 50 % of patients . The number of patients with lack of fatigue and pain symptoms was significantly less in the Chisan ® treatment group than in the placebo group on Days 9 ( 39 % vs . 57 %, pain relief , p = 0.0019 ) and 11 ( 28 % vs . 43 %, relief of fatigue , * p = 0.0157 ). Significant relief of severity of all Long COVID symptoms over the time of treatment and the follow-up period was observed in both groups of patients , notably decreasing the level of anxiety and depression from mild and moderate to normal , as well as increasing cognitive performance in patients in the d2 test for attention and increasing their physical activity and workout ( daily walk time ). However , the significant difference between placebo and Chisan ® treatment was observed only with a workout ( daily walk time ) and relieving respiratory insufficiency ( cough ). A clinical assessment of blood markers of the inflammatory response ( C-reactive protein ) and blood coagulation ( D-dimer ) did not reveal any significant difference over time between treatment groups except significantly lower IL-6 in the Chisan ® treatment group . Furthermore , a significant difference between the placebo and Chisan ® treatment was observed for creatinine : Chisan ® significantly decreased blood creatinine compared to the placebo , suggesting prevention of renal failure progression in Long COVID . In this study , we , for the first time , demonstrate that adaptogens can increase physical performance in Long COVID and reduce the duration of fatigue and chronic pain . It also suggests that Chisan ®/ ADAPT-232 might be useful for preventing the progression of renal failure associated with increasing creatinine .
Prajapati SK , Malaiya A , Mishra G , Jain D , Kesharwani P , Mody N , Ahmadi A , Paliwal R , Jain A . An exhaustive comprehension of the role of herbal medicines in Pre- and Post- COVID manifestations . J Ethnopharmacol . 2022 ; 296:115420 . doi : 10.1016 / j . jep . 2022.115420 .
Ethnopharmacological relevance : The coronavirus disease ( COVID-19 ) has relentlessly spread all over the world even after the advent of vaccines . It demands management , treatment , and prevention as well with utmost safety and effectiveness . It is well researched that herbal medicines or natural products have shown promising outcomes to strengthen immunity with antiviral potential against SARS-COV-2 .
Aim of the review : Our objective is to provide a comprehensive insight into the preventive and therapeutic effects of herbal medicines and products ( Ayurvedic ) for pre-and post-COVID manifestations .
Material and method ; The database used in the text is collected and compiled from Scopus , PubMed , Nature , Elsevier , Web of Science , bioRxiv , medRxiv , American Chemical Society , and clinicaltrials . gov up to January 2022 . Articles from non-academic sources such as websites and news were also retrieved . Exploration of the studies was executed to recognize supplementary publications of research studies and systematic reviews . The keywords , such as " SARS-COV-2 , coronavirus , COVID-19 , herbal drugs , immunity , herbal immunomodulators , infection , herbal antiviral drugs , and WHO recommendation " were thoroughly searched . Chemical structures were drawn using the software Chemdraw Professional 15.0.0.160 ( PerkinElmer Informatics , Inc .).
Result : A plethora of literature supports that the use of herbal regimens not only strengthen immunity but can also treat SARS-COV-2 infection with minimal side effects . This review summarizes the mechanistic insights into herbal therapy engaging interferons and antibodies to boost the response against SARS-COV-2 infection , several clinical trials , and in silico studies ( computational approaches ) on selected natural products including , Ashwagandha , Guduchi , Yashtimadhu , Tulsi , etc . as preventive and therapeutic measures against COVID . We have also emphasized the exploitation of herbal medicine-based pharmaceutical products along with perspectives for unseen upcoming alike diseases .
Conclusion : According to the current state of art and cutting-edge research on herbal medicines have showed a significant promise as modern COVID tools . Since vaccination cannot be purported as a long-term cure for viral infections , herbal / natural medicines can only be considered a viable alternative to current remedies , as conceived from our collected data to unroot recurring viral infections .
Mukherjee PK , Efferth T , Das B , Kar A , Ghosh S , Singha S , Debnath P , Sharma N , Bhardwaj PK , Haldar PK . Role of medicinal plants in inhibiting SARS-CoV-2 and in the management of post-COVID-19 complications . Phytomedicine . 2022 ; 98:153930 . doi : 10.1016 / j . phymed . 2022.153930
Background : The worldwide corona virus disease outbreak , generally known as COVID-19 pandemic outbreak resulted in a major health crisis globally . The morbidity and transmission modality of COVID-19 appear more severe and uncontrollable . The respiratory failure and following cardiovascular complications are the main pathophysiology of this deadly disease . Several therapeutic strategies are put forward for the development of safe and effective treatment against SARS- CoV-2 virus from the pharmacological view point but till date there are no specific treatment regimen developed for this viral infection .
Purpose : The present review emphasizes the role of herbs and herbs-derived secondary metabolites in inhibiting SARS-CoV-2 virus and also for the management of post-COVID-19 related complications . This approach will foster and ensure the safeguards of using medicinal plant resources to support the healthcare system . Plant-derived
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