fatigue scores in general fatigue and sleep / rest fatigue . The results showed a significant improvement of fatigue over the study period . Even though prescriptions were individualised , Cadmium Sulfuricum was the chosen remedy at the start of each case .
5 . Pandey V . Hay Fever and Homeopathy : A Case Series Evaluation . Homeopathy , 2016 , 105 , 202-208 . This uncontrolled UK research assessed the clinical effectiveness of individualised homeopathic treatment in the alleviation of hay fever symptoms in a typical clinical setting . Eight people diagnosed with hay fever completed a Measure Yourself Medical Outcome Profile ( MYMOP ) self-evaluation questionnaire at baseline and again after two weeks and four weeks of homeopathic treatment . The average MYMOP scores for the eyes , nose , and general wellbeing had improved significantly after two and four weeks of homeopathic treatment . The overall average MYMOP profile score at baseline was 3.83 . After 14 and 28 days of treatment the average score had fallen to 1.14 and 1.06 respectively .
6 . Taylor JA , Jacobs J . Homeopathic Treatment of Respiratory Illnesses in Children : Results From Two Randomized Trials . Homeopathy , 2016 , 105 , 15 . University of Washington researchers carried out investigations to determine what effects , if any , homeopathic preparations provided in the treatment of Acute Otitis Media ( AOM ) or Upper Respiratory Tract Infection ( URTI ) in children . In the first study , children aged 6 months to 11 years , diagnosed with AOM and managed with a delayed antibiotic approach , were randomised to standard therapy alone or standard therapy plus a homeopathic ear drop preparation . The primary outcome was whether or not an antibiotic prescription given at the index visit was filled ; and any subsequent antibiotic use was a secondary outcome . During the 12 – 15- day follow-up period significantly fewer parents of children randomised to the homeopathic ear drops group filled the antibiotic prescription compared to those of children receiving standard therapy alone ( 26.9 % and 41.2 %, respectively ). In the second study , children aged 2-5 years diagnosed with an URTI were randomised to receive a homeopathic combination product for cold and cough , or a placebo . Parents were instructed to give a dose of study medication as needed for the relief of URTI symptoms up to 6 times per day for three days . Parents recorded changes in symptoms 1 hour after each dose , as well as changes in overall severity of URTI symptoms in twice daily diaries . The homeopathic group reported a statistically significant improvement in 3 of the 4 URTI symptoms at 12 and 24 hours after enrolment as well in a composite cold score .
In-Vitro Studies
1 . Olioso D , et al . Arnica Montana Effects on Gene Expression in a Human Macrophage Cell Line . Evaluation by Quantitative Real- Time PCR . Homeopathy , 2016 , 105 , 131-147 . This work from Italy examined the mechanism of action of various potencies of homeopathically prepared Arnica ( 2C to 15C ) on wound healing . Quantitative Reverse Transcription Polymerase Chain Reaction ( PCR ) analysis was used to study the changes in the expression of a customised panel of key genes , mainly cytokines , receptors and transcription factors . The results showed that for macrophages differentiated towards the wound-healing phenotype , Arnica affected the expression of several genes , in particular , CXC chemokine ligand 1 ( CXCL1 ), coding for a chief chemokine , and that this exhibited the most consistent increase of expression , while CXC chemokine ligand 2 ( CXCL2 ), Interleukin8 ( IL8 ) and bone morphogenetic protein ( BMP2 ) were slightly up-regulated , suggesting a positive influence of Arnica on neutrophil recruitment and on angiogenesis . MMP1 , coding for a metalloproteinase capable of cleaving extracellular matrix substrates , was down-regulated .
2 . Pastelin LD , Pichardo CO , Velazquez GA . Evaluation of Cytotoxic and Apoptotic Effects of Several Homeopathic Dilutions of Echinacea Angustifolia on Human Breast , Cervical and Prostate Cancer Cells and Genotoxic Study of E . angustifolia MT . Homeopathy , 2016 , 105 , 8 . This Mexican study looked at the in-vitro anti-cancer effects of various homeopathically prepared potencies of Echinacea ( mother tincture , 6C , 30C , 200C , and 1M ) on different human cancer cell lines- MDA-MB-231 ( Breast cancer ), HeLa ( Cervical cancer ) and PC-3 ( Prostate cancer ). Cytotoxicity was measured using the 3- ( 4,5-dimethylthiazolyl-2 ) - 2,5-iphenyltetrazolium bromide ( MTT ) method . Apoptosis was determined by Annexin-V with flow cytometry . Cytotoxicity was measured on peripheral blood mononucleated cells ( PBMC ). Genotoxicity was evaluated by Ames test ( in vitro ) and Micronucleus assay ( in vivo ). The use of Echinacea was associated with a viability reduction of between approximately 70 and 89 % in the MDA-MB-231 cells , and a viability reduction of between approximately 40 and 96 % for HeLa cells , when compared to controls . No viability reduction was seen in the PC-3 cells .
3 . do Nascimento HF , et al . In Vitro Assessment of Anticytotoxic and Antigenotoxic Effects of Canova . Homeopathy , 2016 , 105 , 3 , 265-269 . This research sought to determine the in-vitro antigenotoxic and anticytotoxic effects of a combination of homeopathically prepared ingredients ( Canova ) on human lymphocytes exposed to N-methyl-N-nitrosourea ( NMU ). NMU is an N-nitroso compound , with genotoxic / mutagenic properties . Samples of human lymphocytes that were subjected to different concentrations of a mixture containing Canova and NMU were used . The genotoxicity / antigenotoxicity of Canova was evaluated by the comet assay , and anticytotoxicity
146 | vol28 | no3 | JATMS