activity, antiviral activity, and antiparasitic activity. Therefore, garlic which is easy to grow everywhere, commonly used as daily food seasoning and traditional panacea. We have shown that allicin, in freshly crushed garlic cloves is able to bond the active site of tubulin polymerization in microtubule formation, so that allicin is feasible as the Potential Antimalarial Therapy in East Asian.
4. CONCLUSION Allicin which obtained from Garlic can be a brand new alternative antimalaria medicine by inhibiting microtubule of malaria parasite, Plasmodium falciparum. Allicin strongly binds and inactivates beta-tubulin microtubule protein of Plasmodium falciparum in their active site, Alanine 206, through Alkyl bond and block Cell Division by Preventing Spindle Formation resulting in inhibition of sporozoite invasion and infectivity of Plasmodium falciparum. Allicin is highly recommended for all of East Asian continents because garlic is easy to be grown and well-known in East Asian as a common daily food seasoning and traditional panacea.
5. SUGGESTION We realize there are some aspects that could be further developed on this paper, so we recommend the other authors to develop therapies to the clinical trial because eventually Allicin will be applied as antimalarial for humans. We also suggest to conduct a trial in other Plasmodium species such as Plasmodium vivax and Plasmodium ovale because both are also has the potential transmission of malaria in the world.
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