activity , antiviral activity , and antiparasitic activity . Therefore , garlic which is easy to grow everywhere , commonly used as daily food seasoning and traditional panacea . We have shown that allicin , in freshly crushed garlic cloves is able to bond the active site of tubulin polymerization in microtubule formation , so that allicin is feasible as the Potential Antimalarial Therapy in East Asian .
4 . CONCLUSION Allicin which obtained from Garlic can be a brand new alternative antimalaria medicine by inhibiting microtubule of malaria parasite , Plasmodium falciparum . Allicin strongly binds and inactivates beta-tubulin microtubule protein of Plasmodium falciparum in their active site , Alanine 206 , through Alkyl bond and block Cell Division by Preventing Spindle Formation resulting in inhibition of sporozoite invasion and infectivity of Plasmodium falciparum . Allicin is highly recommended for all of East Asian continents because garlic is easy to be grown and well-known in East Asian as a common daily food seasoning and traditional panacea .
5 . SUGGESTION We realize there are some aspects that could be further developed on this paper , so we recommend the other authors to develop therapies to the clinical trial because eventually Allicin will be applied as antimalarial for humans . We also suggest to conduct a trial in other Plasmodium species such as Plasmodium vivax and Plasmodium ovale because both are also has the potential transmission of malaria in the world .
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