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DISCOVER - HCM - A registry to deliver insights in hypertronic cardiomyopathy and observational outcomes in the real world . United States prospective registry study . Principal investigator : Robert Gottlieb , MD , PhD .
DISRUPT CAD DUO - A prospective , multi-center , single arm IDE study of the Shockwave Coronary Intravascular Lithotripsy ( IVL ) system with the Shockwave C2-2Hz Coronary IVL catheter in calcified coronary arteries . Principal investigator - Robert Stoler , MD .
EARLY TAVR - A prospective , controlled , multi-center study . Patients will be randomized 1:1 to receive either transcatheter aortic valve replacement ( TAVR ) with the Edwards SAPIEN 3 THV or clinical surveillance ( CS ). Patients are stratified by whether or not they are able to perform a treadmill stress test ; in addition , patients who are screened for enrollment but have a positive stress test will be followed in a registry to collect data on subsequent treatment and mortality , as applicable . Lead investigator Dallas site : Robert Stoler , MD .
ECMO-CARD CCC - COVID-19 Critical Care Consortium : Cardiac Sub-Study . Principal investigator : Dan Meyer , MD .
EVAHEART - This is a prospective , multi-center , unblinded , randomized , controlled , and noninferiority study comparing the EVA2 LVAS to the most recent magnetically levitated centrifugal LVAS ( HM3 LVAS ). Principal investigator : Dan Meyer , MD .
EVOLVE 4.5 / 5.0 - A US post-approval study to prove the safety and effectiveness of the Synergy 4.50 / 5.0 mm Everolimus-Eluting Platinum Chromium Coronary Stent System for treatment of atherosclerotic lesions . Principal investigator : Robert Stoler , MD .
EXCEED - A prospective , single-arm , controlled , multicenter study to establish the safety and effectiveness of the CENTERA THV system in intermediate risk patients who have symptomatic , severe , calcific , aortic stenosis requiring aortic valve replacement . Principal investigator : Robert Stoler , MD .
EXERCISE IN IMPELLA - Comparing outcomes of a comprehensive exercise training program versus usual care in patients with axillary impella as a bridge to transplant or left ventricular assistive device . Principal investigator : Annie Gumieny , DPT .
EZDB - A Phase 2 , randomized double-blind , placebo-controlled study to investigate the efficacy and safety of LY3540378 in adults with worsening chronic heart failure with preserved ejection fraction ( HFpEF ). Principal investigator : Cesar Guerrero- Miranda , MD .
FASTr - Fluid management of acute decompensated heart failure subjects treated with Reprieve decongestant management system . Principal investigator : Robert Gottlieb , MD , PhD .
GUIDE HF - Hemodynamic-GUIDEDd management of heart failure . Principal investigator : Shelley Hall , MD .
GUARDIAN REGISTRY - Global Utilization and Registry Database for Improved Heart Preservation . Principal investigator : Dan Meyer , MD .
HELIOS-A - A phase 3 global , controlled , open-label study to evaluate the efficacy and safety of ALN- TTRSC02 in patients with hereditary transthyretin amyloidosis ( hATTR Amyloidosis ). Principal investigator : Parag Kale , MD .
HEP C TRANSPLANT COLLABORATIVE – A nationwide Hepatitis C NAT + Cardiac Transplant Experience . Principal investigator : Shelley Hall , MD .
HLA IN BRIDGE TO TRANSPLANT LVAD – De Novo Anti-Human Leukocyte Antigen Antibodies Production in Patients Bridged by Temporary Mechanical Circlulatory Support Devices to Orthotopic Heart Transplantation : A Prospective Analysis . Principal investigator : Amit Alam , MD .
INNAVASC - This study evaluates the safety and effectiveness of the InnAVasc AVG for hemodialysis access in patients with ESRD . The safety and the effectiveness of the device and the procedure will be assessed using separate primary endpoints through six months . Principal investigator : Stephen Hohmann , MD .
INTERMACS – The Intermacs registry is a national quality improvement system designed to advance the understanding and application of mechanical circulatory support in order to improve the duration and quality of life in patients with advanced heart failure . Principal investigator : Dan Meyer , MD .
Baylor Scott & White Heart and Vascular Hospital | Clinical Trials and Research