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Baylor Scott & White Heart and Vascular Hospital | Clinical Trials and Research
Baylor Scott & White Research Institute — Dallas site
ACURATE CAS - Acurate transfemoral aortic valve system is compared to other commercially available valves that can be delivered without open heart surgery . Principal investigator : Robert Stoler , MD .
AGENT™ – The purpose of the trial is to assess the safety and effectiveness of the Agent™ Paclitaxel Coated PTCA Balloon Catheter compared to balloon angioplasty ( POBA ) in patients with in-stent restenosis ( ISR ) of a previously treated lesion of up to 26 mm in length ( by visual estimate ) in a native coronary artery 2.0 mm to 4.0 mm in diameter . Principal investigator : Robert Stoler , MD .
AIM Higher - Assessment of implantable cardiac contractility modulation ( CCM ) in the heart failure group with higher ejection fraction . This study aims to evaluate the efficacy and safety of CCM therapy in patients with symptomatic heart failure and ejection fraction in the range of 40 to 60 %. Principal investigator : Amarinder Bindra , MD .
ALL-IN – A study to evaluate if Tocilizumab will , when given with standard anti-rejection medicines , lead to better heart transplantation outcomes at one year after the transplant , with less rejection , less development of unwanted antibodies , and better heart function . Principal investigator : Shelley Hall , MD .
ALLIANCE - A study to evaluate the safety and effectiveness of balloon-expandable bioprosthetic SAPIEN X4 transcatheter heart valve . Principal investigator : Robert Stoler , MD .
ALLOSURE - CPET EXERCISE – This study uses AlloSure test characteristics in immunologically quiescent and immunologically active heart transplant recipients . Assessing maximal cardiopulmonary stress testing prior to assay and the preservation of test specificity while enhancing sensitivity . Principal investigator : Robert Gottlieb , MD , PhD .
APOLLO-B EXPANDED ACCESS PROGRAM - Expanded access protocol to provide patisiran to patients with transthyretinmediated amyloidosis ( ATTR amyloidosis ) with cardiomyopathy . Principal investigator : Robert Gottlieb , MD , PhD .
ARIES HM3 - Prospective , randomized , doubleblinded , placebo-controlled clinical investigation of advanced heart failure patients treated with the HM3 with two different antithrombotic regimens : vitamin K antagonist with aspirin versus vitamin K antagonist with placebo . Principal investigator : Shelley Hall , MD .
BACKBEAT STUDY - an industry sponsored study looking at adjusting pacing intervals to control blood pressure in patients who meet indications to have permanent pacemakers . Principal investigator : Manish D . Assar MD .
BARIATRIC SURGERY ON CARDIOVASCULAR FUNCTION - The purpose of this study is to collect data from patients with advanced heart failure undergoing bariatric surgery to investigate the short-term and long-term outcomes of weight loss surgery on patients with heart failure . Principal investigator : Daniel Davis , DO .
BICARB PURGE FLUID STUDY - Feasibility of bicarbonate-based purge fluid in Abiomed Impella Device Implantation . Principal investigator : Cesar Guerrero-Miranda , MD .
BIOFLOW VII - The purpose of this post-approval study is to confirm that the clinical performance of the Orsiro ® stent in a real-world setting is similar to the clinical performance observed for Orsiro in the BIOFLOW-V Investigational Device Exemption pivotal trial . Principal investigator : Robert Stoler , MD .
CARMAT TOTAL ARTIFICIAL HEART - Evaluate the safety and performance of the Carmat Total Artificial Heart in subjects with advanced heart failure requiring biventricular support . Baylor University Medical Center is one of seven sites participating in this bridge-to-transplant study for advanced heart failure patients . Principal investigator : Dan Meyer , MD .
CORCINCH-HF - A randomized GDMT vs AccuCinch Ventricular Restoration Systm and GDMT in patients who have symptomatic HFrEF . Principal investigator : Yashasvi Chugh , MD .
CSWG / SHOCK 1000 – Shock 1000 multi-center registry . Principal investigator : Shelley Hall , MD .
DAPA ACT HF - A multi-center , randomized , double-blind , parallel group , placebo-controlled trial to evaluate the effect of in-hospital initiation of dapagliflozin on clinical outcomes in patients with heart failure with reduced ejection fraction who have been stabilized during hospitalization for acute heart failure . Principal investigator : Amarinder Bindra , MD .
DCD Rejection - DCD Rejection - Factors affecting acute rejection in DCD transplantation . Principal investigator : Katharina Fetten , MD .